Analysis of associations between risk factors for cardiovascular disease and breast cancer
ObjectiveTo explore the associations between risk factors for cardiovascular disease and breast cancer. MethodsA total of 300 patients with breast cancer and 300 with benign breast diseases diagnosed by postoperative pathology were included in the Department of Breast Surgery, Huangpu Branch of the...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shanghai Chinese Clinical Medicine Press Co., Ltd.
2024-12-01
|
| Series: | Zhongguo Linchuang Yixue |
| Subjects: | |
| Online Access: | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2024.20240861 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850252824073469952 |
|---|---|
| author | Ruijie NIU Jun ZENG Zhoutong LI Cheng WANG Jinquan JIANG |
| author_facet | Ruijie NIU Jun ZENG Zhoutong LI Cheng WANG Jinquan JIANG |
| author_sort | Ruijie NIU |
| collection | DOAJ |
| description | ObjectiveTo explore the associations between risk factors for cardiovascular disease and breast cancer. MethodsA total of 300 patients with breast cancer and 300 with benign breast diseases diagnosed by postoperative pathology were included in the Department of Breast Surgery, Huangpu Branch of the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine from January 2023 to June 2023. The main cardiovascular risk factors in patients between the two groups were compared. Stratification was performed according to menstrual status, and the main cardiovascular risk factors in patients with different menstrual status between the two groups were compared. The logistic regression correlation analysis was used to analyze the risk factors related to cardiovascular disease for breast cancer. ResultsThere were statistically significant differences in clinical data and laboratory indicators between the two groups (P＜0.01) . Multivariate logistic regression analysis showed that age (OR=1.03, P=0.029), triglyceride (TG; OR=1.94, P=0.025), C-reactive protein (CRP; OR=2.73, P＜0.001), D-dimer (OR=61.19, P＜0.001), and homocysteine (Hcy; OR=2.10, P＜0.001) were independently associated with breast cancer. The stratified analysis showed age, TG, CRP, D-dimer, and Hcy were independently associated with breast cancer in both premenopausal and postmenopausal patients (P＜0.05). ConclusionsAmong risk factors for cardiovascular disease, advanced age, increased TG, CRP, D-dimer, and Hcy might increase breast cancer risk, which are helpful of screening high-risk individuals for breast cancer. |
| format | Article |
| id | doaj-art-bce4c8a711734ac685d12e1a353b7187 |
| institution | OA Journals |
| issn | 1008-6358 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Shanghai Chinese Clinical Medicine Press Co., Ltd. |
| record_format | Article |
| series | Zhongguo Linchuang Yixue |
| spelling | doaj-art-bce4c8a711734ac685d12e1a353b71872025-08-20T01:57:32ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582024-12-0131693293810.12025/j.issn.1008-6358.2024.2024086120240861Analysis of associations between risk factors for cardiovascular disease and breast cancerRuijie NIU0Jun ZENG1Zhoutong LI2Cheng WANG3Jinquan JIANG4Department of Breast Surgery, Huangpu Branch, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaDepartment of Cardiology, Huangpu Branch, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaDepartment of Cardiology, Huangpu Branch, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaDepartment of Breast Surgery, Huangpu Branch, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaDepartment of Cardiology, Huangpu Branch, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaObjectiveTo explore the associations between risk factors for cardiovascular disease and breast cancer. MethodsA total of 300 patients with breast cancer and 300 with benign breast diseases diagnosed by postoperative pathology were included in the Department of Breast Surgery, Huangpu Branch of the Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine from January 2023 to June 2023. The main cardiovascular risk factors in patients between the two groups were compared. Stratification was performed according to menstrual status, and the main cardiovascular risk factors in patients with different menstrual status between the two groups were compared. The logistic regression correlation analysis was used to analyze the risk factors related to cardiovascular disease for breast cancer. ResultsThere were statistically significant differences in clinical data and laboratory indicators between the two groups (P＜0.01) . Multivariate logistic regression analysis showed that age (OR=1.03, P=0.029), triglyceride (TG; OR=1.94, P=0.025), C-reactive protein (CRP; OR=2.73, P＜0.001), D-dimer (OR=61.19, P＜0.001), and homocysteine (Hcy; OR=2.10, P＜0.001) were independently associated with breast cancer. The stratified analysis showed age, TG, CRP, D-dimer, and Hcy were independently associated with breast cancer in both premenopausal and postmenopausal patients (P＜0.05). ConclusionsAmong risk factors for cardiovascular disease, advanced age, increased TG, CRP, D-dimer, and Hcy might increase breast cancer risk, which are helpful of screening high-risk individuals for breast cancer.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2024.20240861breast cancercardiovascular diseasecardio-oncologyrisk factor |
| spellingShingle | Ruijie NIU Jun ZENG Zhoutong LI Cheng WANG Jinquan JIANG Analysis of associations between risk factors for cardiovascular disease and breast cancer Zhongguo Linchuang Yixue breast cancer cardiovascular disease cardio-oncology risk factor |
| title | Analysis of associations between risk factors for cardiovascular disease and breast cancer |
| title_full | Analysis of associations between risk factors for cardiovascular disease and breast cancer |
| title_fullStr | Analysis of associations between risk factors for cardiovascular disease and breast cancer |
| title_full_unstemmed | Analysis of associations between risk factors for cardiovascular disease and breast cancer |
| title_short | Analysis of associations between risk factors for cardiovascular disease and breast cancer |
| title_sort | analysis of associations between risk factors for cardiovascular disease and breast cancer |
| topic | breast cancer cardiovascular disease cardio-oncology risk factor |
| url | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2024.20240861 |
| work_keys_str_mv | AT ruijieniu analysisofassociationsbetweenriskfactorsforcardiovasculardiseaseandbreastcancer AT junzeng analysisofassociationsbetweenriskfactorsforcardiovasculardiseaseandbreastcancer AT zhoutongli analysisofassociationsbetweenriskfactorsforcardiovasculardiseaseandbreastcancer AT chengwang analysisofassociationsbetweenriskfactorsforcardiovasculardiseaseandbreastcancer AT jinquanjiang analysisofassociationsbetweenriskfactorsforcardiovasculardiseaseandbreastcancer |