Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies

Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies

Saved in:

Bibliographic Details
Main Authors:	Dan Zhang, Jifa Zhang, Chengyong Wu, Yao Xiao, Liwei Ji, Jiarui Hu, Jianjun Ding, Tao Li, Yiwen Zhang, Liang Ouyang
Format:	Article
Language:	English
Published:	American Chemical Society 2025-04-01
Series:	ACS Central Science
Online Access:	https://doi.org/10.1021/acscentsci.5c00023
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Epigenetic Mechanisms of Cardioprotection: Focus is on Activation of Sirtuins
by: K. A. Aitbaev, et al.
Published: (2021-11-01)

How does a small molecule bind at a cryptic binding site?
by: Yibing Shan, et al.
Published: (2022-03-01)

Identification of druggable binding sites and small molecules as modulators of TMC1
by: Pedro De-la-Torre, et al.
Published: (2025-05-01)

Cardioprotection Through Pharmacological Activation of Sirtuin 5 in a Murine Model of Acute Myocardial Infarction
by: Castiello C, et al.
Published: (2025-06-01)

Identification of a binding site for small molecule inhibitors targeting human TRPM4
by: Babatunde Ekundayo, et al.
Published: (2025-01-01)

The Relationship of Sirtuin 1 and Sirtuin 2 Expression with Clinicopathological Parameters in Non Small-Cell Lung Carcinomas
by: Fatma Cakmak Kazanci, et al.
Published: (2024-11-01)

Global analysis of small molecule binding to related protein targets.
by: Felix A Kruger, et al.
Published: (2012-01-01)

Small molecule inhibition of RNA binding proteins in haematologic cancer
by: Amit K. Jaiswal, et al.
Published: (2024-12-01)

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
by: Thomas L Prince, et al.
Published: (2015-01-01)

In Silico Characterization of Sirtuins in Acetic Acid Bacteria Reveals a Novel Phylogenetically Distinctive Group
by: Igor Jugović, et al.
Published: (2025-01-01)

Stimulation of Apoptosis by Computationally Derived Small Molecules that Bind to BCL-2
by: Martha Mutomba, et al.
Published: (2001-01-01)

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i>
by: Hovakim Grabski, et al.
Published: (2024-12-01)

Unraveling the site-specific features in small intestinal stromal tumors: a retrospective study
by: Qipu Wang, et al.
Published: (2025-05-01)

Binding memory of liquid molecules
by: Shiyi Qin, et al.
Published: (2025-07-01)

A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor
by: Han Kurt, et al.
Published: (2025-07-01)

Binding Energies of Small Interstellar Molecules on Neutral and Charged Amorphous Solid Water Surfaces
by: Tobe Vorsselmans, et al.
Published: (2025-01-01)

Sirtuins Link Inflammation and Metabolism
by: Vidula T. Vachharajani, et al.
Published: (2016-01-01)

Sirtuin family in lung adenocarcinoma
by: Cui Chen, et al.
Published: (2025-07-01)

Activation of the bacterial defense-associated sirtuin system
by: Kaixiang Zhu, et al.
Published: (2025-02-01)

Identification of heterogeneity and common characteristics in colorectal carcinoma located in distinct sites
by: Yuqi Luo, et al.
Published: (2025-07-01)

Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment
by: Aaron P. Owji, et al.
Published: (2024-12-01)

A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
by: Lior Peri, et al.
Published: (2024-11-01)

Renal Protective Effect of Sirtuin 1
by: Yi-jun Dong, et al.
Published: (2014-01-01)

Sirtuins and Their Role in the Aging Eye (Review)
by: L. K. Moshetova, et al.
Published: (2020-09-01)

Sirtuin 1 and Hormonal Regulations in Aging
by: Milena Keremidarska-Markova, et al.
Published: (2024-12-01)

Targeted protein degradation with small molecules for cancer immunotherapy
by: Zichao Yang, et al.
Published: (2025-08-01)

Protein Quakes in Redox Metalloenzymes: Clues to Molecular Enzyme Conductivity Triggered by Binding of Small Substrate Molecules
by: Henrik Bohr, et al.
Published: (2024-12-01)

CARDIOPROTECTIVE EFFECTS OF PHOSPHOCREATINE
by: V. V. Lomivorotov, et al.
Published: (2018-01-01)

Cardioprotective Properties Of Xenon
by: A. I. Shpichko, et al.
Published: (2020-10-01)

HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators.
by: Tony S Cardno, et al.
Published: (2015-01-01)

Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons
by: Zhenyuan Zhang, et al.
Published: (2025-10-01)

Cell size control is sirtuin(ly) exciting
by: Jill Wright, et al.
Published: (2013-11-01)

Role of sirtuins in epigenetic regulation and aging control
by: E. M. Samoilova, et al.
Published: (2024-04-01)

Sirtuin activators as an anti-aging intervention for longevity
by: Puja Sah, et al.
Published: (2025-01-01)

Sirtuins: Emergent Players in Tissue and Organ Regeneration
by: Ayla Kyler Núñez, et al.
Published: (2024-12-01)

Ensemble-Based Binding Free Energy Profiling and Network Analysis of the KRAS Interactions with DARPin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants and Universal Architecture of Regulatory Hotspots and Allosteric Binding
by: Mohammed Alshahrani, et al.
Published: (2025-06-01)

An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein
by: Sneha Menon, et al.
Published: (2024-12-01)

Small molecule inhibitors targeting the cancers
by: Gui‐Hong Liu, et al.
Published: (2022-12-01)

Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response.
by: Mei Zhong, et al.
Published: (2010-02-01)

Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein.
by: Ilse Jongerius, et al.
Published: (2013-01-01)