Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a Child
Vancomycin is routinely used for empiric antibiotic therapy in children. Higher-serum-concentration targets for serious infections are now being recommended. This recommendation may result in aggressive dosing with increased potential for toxicity. We report a case of a pediatric patient who develop...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2011/678724 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849684997524422656 |
|---|---|
| author | Timothy Stidham Pamela D. Reiter Douglas M. Ford Gary M. Lum Joseph Albietz |
| author_facet | Timothy Stidham Pamela D. Reiter Douglas M. Ford Gary M. Lum Joseph Albietz |
| author_sort | Timothy Stidham |
| collection | DOAJ |
| description | Vancomycin is routinely used for empiric antibiotic therapy in children. Higher-serum-concentration targets for serious infections are now being recommended. This recommendation may result in aggressive dosing with increased potential for toxicity. We report a case of a pediatric patient who developed vancomycin toxicity and associated oliguric renal failure who was treated effectively with high-flux hemodialysis for vancomycin toxicity, clearing serum concentrations of vancomycin by over 75% in only 6 hours (213.2 mcg/mL to 51.8 mcg/mL) with subsequent return to baseline renal function and without adverse sequelae. While not historically considered a viable option for drug removal in cases of toxicity, new high-flux hemodialysis techniques can remove significant percentages of vancomycin in short periods of time. |
| format | Article |
| id | doaj-art-bcdd240eed43451084cd262fe9e67081 |
| institution | DOAJ |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-bcdd240eed43451084cd262fe9e670812025-08-20T03:23:18ZengWileyCase Reports in Pediatrics2090-68032090-68112011-01-01201110.1155/2011/678724678724Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a ChildTimothy Stidham0Pamela D. Reiter1Douglas M. Ford2Gary M. Lum3Joseph Albietz4Pediatric Intensive Care Unit, Section of Critical Care Medicine, Children's Hospital Colorado and University of Colorado at Denver, 13123 East 17th Avenue, Mail Stop 8414, Aurora, CO 80045, USAPediatric Intensive Care Unit, Department of Pharmacy, Center for Pediatric Medicine, Children's Hospital Colorado and University of Colorado Denver School of Pharmacy, 13123 East 17th Avenue, Campus Box 375, Aurora, CO 80045, USADepartment of Nephrology, University of Colorado at Denver and Children's Hospital Colorado, 13123 East 16th Avenue, Campus Box B328, Aurora, CO 80045, USADepartment of Nephrology, University of Colorado at Denver and Children's Hospital Colorado, 13123 East 16th Avenue, Campus Box B328, Aurora, CO 80045, USAPediatric Intensive Care Unit, Section of Critical Care Medicine, University of Colorado at Denver and Children's Hospital Colorado, 13123 East 17th Avenue, Campus Box B530, Aurora, CO 80045, USAVancomycin is routinely used for empiric antibiotic therapy in children. Higher-serum-concentration targets for serious infections are now being recommended. This recommendation may result in aggressive dosing with increased potential for toxicity. We report a case of a pediatric patient who developed vancomycin toxicity and associated oliguric renal failure who was treated effectively with high-flux hemodialysis for vancomycin toxicity, clearing serum concentrations of vancomycin by over 75% in only 6 hours (213.2 mcg/mL to 51.8 mcg/mL) with subsequent return to baseline renal function and without adverse sequelae. While not historically considered a viable option for drug removal in cases of toxicity, new high-flux hemodialysis techniques can remove significant percentages of vancomycin in short periods of time.http://dx.doi.org/10.1155/2011/678724 |
| spellingShingle | Timothy Stidham Pamela D. Reiter Douglas M. Ford Gary M. Lum Joseph Albietz Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a Child Case Reports in Pediatrics |
| title | Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a Child |
| title_full | Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a Child |
| title_fullStr | Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a Child |
| title_full_unstemmed | Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a Child |
| title_short | Successful Utilization of High-Flux Hemodialysis for Treatment of Vancomycin Toxicity in a Child |
| title_sort | successful utilization of high flux hemodialysis for treatment of vancomycin toxicity in a child |
| url | http://dx.doi.org/10.1155/2011/678724 |
| work_keys_str_mv | AT timothystidham successfulutilizationofhighfluxhemodialysisfortreatmentofvancomycintoxicityinachild AT pameladreiter successfulutilizationofhighfluxhemodialysisfortreatmentofvancomycintoxicityinachild AT douglasmford successfulutilizationofhighfluxhemodialysisfortreatmentofvancomycintoxicityinachild AT garymlum successfulutilizationofhighfluxhemodialysisfortreatmentofvancomycintoxicityinachild AT josephalbietz successfulutilizationofhighfluxhemodialysisfortreatmentofvancomycintoxicityinachild |