Regulation of L-Lactate in Glutamate Excitotoxicity Under Cerebral Ischemia: Pathophysiology and Preventive Strategy

Regulation of L-Lactate in Glutamate Excitotoxicity Under Cerebral Ischemia: Pathophysiology and Preventive Strategy

Glutamate is an excitatory neurotransmitter in the central nervous system (CNS) that mediates synaptic transmission. However, glutamate homeostasis among neural cells is broken in cerebral ischemia. Excessive glutamate triggers <i>N</i>-methyl-<span style="font-variant: small-cap...

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Bibliographic Details
Main Authors:	Mao Zhang, Yanyan Wang, Zili Gong, Wen Jiang, Guodong Ge, Hong Guo
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Pharmaceuticals
Subjects:	cerebral ischemia L-lactate glutamate calcium overload astroglial L-lactate-sensitive receptor (LLR)
Online Access:	https://www.mdpi.com/1424-8247/18/7/935
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