Breast cancer in East Africa: Prevalence and spectrum of germline SNV/indel and CNVs in BRCA1 and BRCA2 genes among breast cancer patients in Tanzania

Breast cancer in East Africa: Prevalence and spectrum of germline SNV/indel and CNVs in BRCA1 and BRCA2 genes among breast cancer patients in Tanzania

Abstract Background Growing prevalence and aggressiveness of breast cancer (BC) among East African women strongly indicate that the genetic risk factor implicated in the etiology of the disease may have a key role. Germline pathogenic variants in BRCA1 and BRCA2 (BRCA1/2) are known to increase the l...

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Bibliographic Details
Main Authors: Linus P. Rweyemamu, Büşra K. Gültaşlar, Gokce Akan, Nazima Dharsee, Lucy A. Namkinga, Sylvester L. Lyantagaye, Hülya Yazıcı, Fatmahan Atalar
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Cancer Medicine
Subjects:
BRCA1/2
breast cancer
germline mutations
next‐generation sequencing
Tanzania
Online Access:https://doi.org/10.1002/cam4.5091
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