Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis
Objective To investigate the clinical application of plasma lipoprotein-associated phospholipase phospholipaseA<sub>2</sub>（Lp-PLA<sub>2</sub>） levels in evaluation of structure and function of heart in patients undergoing maintenance hemodialysis（MHD）.Methods Seventy MHD pat...
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Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | WANG Yun-qian CHEN Bao-ping SHI Jun |
| author_facet | WANG Yun-qian CHEN Bao-ping SHI Jun |
| author_sort | WANG Yun-qian |
| collection | DOAJ |
| description | Objective To investigate the clinical application of plasma lipoprotein-associated phospholipase phospholipaseA<sub>2</sub>（Lp-PLA<sub>2</sub>） levels in evaluation of structure and function of heart in patients undergoing maintenance hemodialysis（MHD）.Methods Seventy MHD patients were involved in the study,who were treated with MHD for at least 6 months before the study and in a stable clinical status.The plasma Lp-PLA<sub>2</sub> levels were examined by ELISA.The serum B-type natriuretic peptide（BNP） levels were measured by immunofluorescent assay.The parameters of left ventricular end-diastolic diameter（LVEDD）,left atrial diameter（LAD）,left ventricular posterior wall depth（LVPWD） and left ventricular ejection fraction（LVEF） were measured by cardiac color ultrasound,the left ventricular mass index(LVMD was calculated,and the relationship between plasma Lp-PLA<sub>2</sub> levels and parameters determined by cardiac color ultrasound was analyzed.Another 40 healthy volunteers served as normal control group.Results（1） The levels of Lp-PLA<sub>2</sub>,BNP,LVMI,LVEF and systolic pressure in MHD group were significantly higher than those in normal control group（P<0.05）.（2） In MHD group,the patients with abnormal LVEF（LVEF<50%）,left ventricle hypertrophy and/or cardiac insufficiency（BNP>300 ng/L） had higher levels of Lp-PLA<sub>2</sub> than the other patients without abnormal LVEF（LVEF>50%）,left ventricle hypertrophy and/or cardiac sufficiency（BNP<300 ng/L）.（3） The plasma Lp-PLA<sub>2</sub> level was positively correlated with the levels of BNP（r =0.43,P<0.05） and LVMI（r = 0.58,P<0.01）,but negatively with the level of LVEF（r =- 0.67,P<0.01） in patients undergoing MHD.（4） Multiple stepwise regression analysis demonstrated that the plasmaLp-PLA<sub>2</sub> level was correlated with the levels of LVMI（β=0.342,P<0.01）and LVEF（β=- 0.396,P<0.01）.Conclusions Higher plasma Lp-PLA<sub>2</sub> levels extensively exists in patients undergoing MHD.Plasma Lp-PLA<sub>2</sub> level can reflect structure and function of left ventricle,which may play an important role in the evaluation of left ventricular hypertrophy and function of left ventricle. |
| format | Article |
| id | doaj-art-bcd2c63d2d944639a759cfe98d9a613f |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2016-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-bcd2c63d2d944639a759cfe98d9a613f2025-08-20T03:48:58ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902016-01-0130330657919831Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysisWANG Yun-qianCHEN Bao-pingSHI JunObjective To investigate the clinical application of plasma lipoprotein-associated phospholipase phospholipaseA<sub>2</sub>（Lp-PLA<sub>2</sub>） levels in evaluation of structure and function of heart in patients undergoing maintenance hemodialysis（MHD）.Methods Seventy MHD patients were involved in the study,who were treated with MHD for at least 6 months before the study and in a stable clinical status.The plasma Lp-PLA<sub>2</sub> levels were examined by ELISA.The serum B-type natriuretic peptide（BNP） levels were measured by immunofluorescent assay.The parameters of left ventricular end-diastolic diameter（LVEDD）,left atrial diameter（LAD）,left ventricular posterior wall depth（LVPWD） and left ventricular ejection fraction（LVEF） were measured by cardiac color ultrasound,the left ventricular mass index(LVMD was calculated,and the relationship between plasma Lp-PLA<sub>2</sub> levels and parameters determined by cardiac color ultrasound was analyzed.Another 40 healthy volunteers served as normal control group.Results（1） The levels of Lp-PLA<sub>2</sub>,BNP,LVMI,LVEF and systolic pressure in MHD group were significantly higher than those in normal control group（P<0.05）.（2） In MHD group,the patients with abnormal LVEF（LVEF<50%）,left ventricle hypertrophy and/or cardiac insufficiency（BNP>300 ng/L） had higher levels of Lp-PLA<sub>2</sub> than the other patients without abnormal LVEF（LVEF>50%）,left ventricle hypertrophy and/or cardiac sufficiency（BNP<300 ng/L）.（3） The plasma Lp-PLA<sub>2</sub> level was positively correlated with the levels of BNP（r =0.43,P<0.05） and LVMI（r = 0.58,P<0.01）,but negatively with the level of LVEF（r =- 0.67,P<0.01） in patients undergoing MHD.（4） Multiple stepwise regression analysis demonstrated that the plasmaLp-PLA<sub>2</sub> level was correlated with the levels of LVMI（β=0.342,P<0.01）and LVEF（β=- 0.396,P<0.01）.Conclusions Higher plasma Lp-PLA<sub>2</sub> levels extensively exists in patients undergoing MHD.Plasma Lp-PLA<sub>2</sub> level can reflect structure and function of left ventricle,which may play an important role in the evaluation of left ventricular hypertrophy and function of left ventricle.http://www.lcszb.com/thesisDetails?columnId=57919831&Fpath=home&index=0Maintenance hemodialysisLipoprotein-associated phospholipaseA2HeartStructureFunction |
| spellingShingle | WANG Yun-qian CHEN Bao-ping SHI Jun Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis Linchuang shenzangbing zazhi Maintenance hemodialysis Lipoprotein-associated phospholipaseA2 Heart Structure Function |
| title | Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis |
| title_full | Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis |
| title_fullStr | Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis |
| title_full_unstemmed | Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis |
| title_short | Effect of plasma lipoprotein-associated phospholipase A<sub>2</sub> levels on structure and function of heart in patients undergoing maintenance hemodialysis |
| title_sort | effect of plasma lipoprotein associated phospholipase a sub 2 sub levels on structure and function of heart in patients undergoing maintenance hemodialysis |
| topic | Maintenance hemodialysis Lipoprotein-associated phospholipaseA2 Heart Structure Function |
| url | http://www.lcszb.com/thesisDetails?columnId=57919831&Fpath=home&index=0 |
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