GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-Analysis
Background: The correlation among Glucokinase (GCK) rs1799884 polymorphism and the risk of gestational diabetes mellitus (GDM) remains controversial, as previous studies have reported inconsistent findings. The potential relationship among the GCK rs1799884 polymorphism and GDM risk was examined by...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2024-05-01
|
| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/51/5/10.31083/j.ceog5105108 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850242292673150976 |
|---|---|
| author | Yong Hu Ao Wang Ke Yi |
| author_facet | Yong Hu Ao Wang Ke Yi |
| author_sort | Yong Hu |
| collection | DOAJ |
| description | Background: The correlation among Glucokinase (GCK) rs1799884 polymorphism and the risk of gestational diabetes mellitus (GDM) remains controversial, as previous studies have reported inconsistent findings. The potential relationship among the GCK rs1799884 polymorphism and GDM risk was examined by a meta-analysis. Methods: In order to find relevant studies for our investigation, we performed an extensive search across multiple databases, such as Ovid, PubMed, China National Knowledge Infrastructure, and Web of Science. Afterward, the link among the GDM risk and GCK rs1799884 polymorphism was evaluated by employing either random-effects models or fixed-effects to compute 95% confidence intervals (CIs) and pooled odds ratios (ORs). Results: This meta-analysis comprised a total of 11 studies. The findings revealed that the GCK rs1799884 polymorphism was linked to a decreased risk of GDM across all examined models. The pooled analysis demonstrated a substantial link, with the corresponding 95% CIs and the following ORs: Allele contrast: 0.80 (0.73–0.88), recessive model 0.81 (0.76–0.88), homozygote 0.60, (0.49–0.73), heterozygote 0.84, (0.78–0.91), dominant model 0.59, (0.48–0.72). Conclusions: The GCK rs1799884 variant, according to the current meta-analysis, may act as a genetic biomarker of GDM. The investigation was registered on PROSPERO (https://www.crd.york.ac.uk/prospero/) under registration number CRD42023492185. |
| format | Article |
| id | doaj-art-bcd05ac292fb4d8baaf78097aa3eaa6f |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-bcd05ac292fb4d8baaf78097aa3eaa6f2025-08-20T02:00:18ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-05-0151510810.31083/j.ceog5105108S0390-6663(24)02376-5GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-AnalysisYong Hu0Ao Wang1Ke Yi2Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaKey Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaKey Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, West China Second University Hospital, Sichuan University, 610041 Chengdu, Sichuan, ChinaBackground: The correlation among Glucokinase (GCK) rs1799884 polymorphism and the risk of gestational diabetes mellitus (GDM) remains controversial, as previous studies have reported inconsistent findings. The potential relationship among the GCK rs1799884 polymorphism and GDM risk was examined by a meta-analysis. Methods: In order to find relevant studies for our investigation, we performed an extensive search across multiple databases, such as Ovid, PubMed, China National Knowledge Infrastructure, and Web of Science. Afterward, the link among the GDM risk and GCK rs1799884 polymorphism was evaluated by employing either random-effects models or fixed-effects to compute 95% confidence intervals (CIs) and pooled odds ratios (ORs). Results: This meta-analysis comprised a total of 11 studies. The findings revealed that the GCK rs1799884 polymorphism was linked to a decreased risk of GDM across all examined models. The pooled analysis demonstrated a substantial link, with the corresponding 95% CIs and the following ORs: Allele contrast: 0.80 (0.73–0.88), recessive model 0.81 (0.76–0.88), homozygote 0.60, (0.49–0.73), heterozygote 0.84, (0.78–0.91), dominant model 0.59, (0.48–0.72). Conclusions: The GCK rs1799884 variant, according to the current meta-analysis, may act as a genetic biomarker of GDM. The investigation was registered on PROSPERO (https://www.crd.york.ac.uk/prospero/) under registration number CRD42023492185.https://www.imrpress.com/journal/CEOG/51/5/10.31083/j.ceog5105108gestational diabetes mellitusgckpolymorphismsmeta-analysis |
| spellingShingle | Yong Hu Ao Wang Ke Yi GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-Analysis Clinical and Experimental Obstetrics & Gynecology gestational diabetes mellitus gck polymorphisms meta-analysis |
| title | GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-Analysis |
| title_full | GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-Analysis |
| title_fullStr | GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-Analysis |
| title_full_unstemmed | GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-Analysis |
| title_short | GCK rs1799884 Polymorphism and Gestational Diabetes Mellitus: A System Review and Meta-Analysis |
| title_sort | gck rs1799884 polymorphism and gestational diabetes mellitus a system review and meta analysis |
| topic | gestational diabetes mellitus gck polymorphisms meta-analysis |
| url | https://www.imrpress.com/journal/CEOG/51/5/10.31083/j.ceog5105108 |
| work_keys_str_mv | AT yonghu gckrs1799884polymorphismandgestationaldiabetesmellitusasystemreviewandmetaanalysis AT aowang gckrs1799884polymorphismandgestationaldiabetesmellitusasystemreviewandmetaanalysis AT keyi gckrs1799884polymorphismandgestationaldiabetesmellitusasystemreviewandmetaanalysis |