Genetic Predictors of Lithium Response
Lithium remains a first-line pharmacological treatment of bipolar disorder (BD). However, treatment response is heterogeneous, with several lines of evidence implicating genetic factors. Unfortunately, neither hypothesis-driven approaches nor initial genome-wide association studies (GWAS) were succe...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/295 |
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| author | U. Heilbronner |
| author_facet | U. Heilbronner |
| author_sort | U. Heilbronner |
| collection | DOAJ |
| description | Lithium remains a first-line pharmacological treatment of bipolar disorder (BD). However, treatment response is heterogeneous, with several lines of evidence implicating genetic factors. Unfortunately, neither hypothesis-driven approaches nor initial genome-wide association studies (GWAS) were successful in identifying genetic drivers of response heterogeneity, probably due to low statistical power and different phenotype measurements. Recently, a GWAS of the Consortium of Lithium Genetics (ConLiGen) has identified four single nucleotide polymorphisms (SNPs) mediating response to lithium, located in genes for two long non-coding RNAs. This success was only possible by international collaboration and the use of an established lithium response scale. The findings await further replication. |
| format | Article |
| id | doaj-art-bccfd54e9c6243a8931513c4fefee66c |
| institution | DOAJ |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-bccfd54e9c6243a8931513c4fefee66c2025-08-20T03:20:23ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-1262710.31363/2313-7053-2019-4-1-26-27274Genetic Predictors of Lithium ResponseU. Heilbronner0Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU MunichLithium remains a first-line pharmacological treatment of bipolar disorder (BD). However, treatment response is heterogeneous, with several lines of evidence implicating genetic factors. Unfortunately, neither hypothesis-driven approaches nor initial genome-wide association studies (GWAS) were successful in identifying genetic drivers of response heterogeneity, probably due to low statistical power and different phenotype measurements. Recently, a GWAS of the Consortium of Lithium Genetics (ConLiGen) has identified four single nucleotide polymorphisms (SNPs) mediating response to lithium, located in genes for two long non-coding RNAs. This success was only possible by international collaboration and the use of an established lithium response scale. The findings await further replication.https://www.bekhterevreview.com/jour/article/view/295bipolar disordermedicationgwasresponsealda scalelong non-coding rna |
| spellingShingle | U. Heilbronner Genetic Predictors of Lithium Response Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева bipolar disorder medication gwas response alda scale long non-coding rna |
| title | Genetic Predictors of Lithium Response |
| title_full | Genetic Predictors of Lithium Response |
| title_fullStr | Genetic Predictors of Lithium Response |
| title_full_unstemmed | Genetic Predictors of Lithium Response |
| title_short | Genetic Predictors of Lithium Response |
| title_sort | genetic predictors of lithium response |
| topic | bipolar disorder medication gwas response alda scale long non-coding rna |
| url | https://www.bekhterevreview.com/jour/article/view/295 |
| work_keys_str_mv | AT uheilbronner geneticpredictorsoflithiumresponse |