Novel targeted therapies for immunoglobulin light chain amyloidosis: latest updates from the 2024 ASH annual meeting
Abstract Immunoglobulin light chain (AL) amyloidosis is an incurable disease caused by the accumulation and sedimentation of unstable free light chains produced by monoclonal plasma cells. The key to treatment is to achieve a deep hematologic remission in order to improve organ function or reverse o...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Journal of Hematology & Oncology |
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| Online Access: | https://doi.org/10.1186/s13045-025-01681-7 |
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| author | Qiling Bu Hong-Hu Zhu Wenming Chen |
| author_facet | Qiling Bu Hong-Hu Zhu Wenming Chen |
| author_sort | Qiling Bu |
| collection | DOAJ |
| description | Abstract Immunoglobulin light chain (AL) amyloidosis is an incurable disease caused by the accumulation and sedimentation of unstable free light chains produced by monoclonal plasma cells. The key to treatment is to achieve a deep hematologic remission in order to improve organ function or reverse organ dysfunction. Conventional treatment has not been able to fully meet the treatment needs of patients with AL, while therapies targeting malignant plasma cells or amyloid have potentially improved treatment outcomes. This study provides an overview of the latest reports on targeted therapies for AL amyloidosis from the 2024 ASH Annual Meeting. |
| format | Article |
| id | doaj-art-bccc0410dde64468b5ae854d010bf5fc |
| institution | DOAJ |
| issn | 1756-8722 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj-art-bccc0410dde64468b5ae854d010bf5fc2025-08-20T02:47:07ZengBMCJournal of Hematology & Oncology1756-87222025-03-011811410.1186/s13045-025-01681-7Novel targeted therapies for immunoglobulin light chain amyloidosis: latest updates from the 2024 ASH annual meetingQiling Bu0Hong-Hu Zhu1Wenming Chen2Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Hematology, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Hematology, Beijing Chao-Yang Hospital, Capital Medical UniversityAbstract Immunoglobulin light chain (AL) amyloidosis is an incurable disease caused by the accumulation and sedimentation of unstable free light chains produced by monoclonal plasma cells. The key to treatment is to achieve a deep hematologic remission in order to improve organ function or reverse organ dysfunction. Conventional treatment has not been able to fully meet the treatment needs of patients with AL, while therapies targeting malignant plasma cells or amyloid have potentially improved treatment outcomes. This study provides an overview of the latest reports on targeted therapies for AL amyloidosis from the 2024 ASH Annual Meeting.https://doi.org/10.1186/s13045-025-01681-7Immunoglobulin light chain amyloidosisTargeted therapiesClinical trials |
| spellingShingle | Qiling Bu Hong-Hu Zhu Wenming Chen Novel targeted therapies for immunoglobulin light chain amyloidosis: latest updates from the 2024 ASH annual meeting Journal of Hematology & Oncology Immunoglobulin light chain amyloidosis Targeted therapies Clinical trials |
| title | Novel targeted therapies for immunoglobulin light chain amyloidosis: latest updates from the 2024 ASH annual meeting |
| title_full | Novel targeted therapies for immunoglobulin light chain amyloidosis: latest updates from the 2024 ASH annual meeting |
| title_fullStr | Novel targeted therapies for immunoglobulin light chain amyloidosis: latest updates from the 2024 ASH annual meeting |
| title_full_unstemmed | Novel targeted therapies for immunoglobulin light chain amyloidosis: latest updates from the 2024 ASH annual meeting |
| title_short | Novel targeted therapies for immunoglobulin light chain amyloidosis: latest updates from the 2024 ASH annual meeting |
| title_sort | novel targeted therapies for immunoglobulin light chain amyloidosis latest updates from the 2024 ash annual meeting |
| topic | Immunoglobulin light chain amyloidosis Targeted therapies Clinical trials |
| url | https://doi.org/10.1186/s13045-025-01681-7 |
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