Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets
The renin-angiotensin-aldosterone system (RAAS) plays a fundamental role in regulating blood pressure and fluid homeostasis through key effectors such as angiotensin II and aldosterone. These agents and their receptors have become crucial molecular targets in several cardiovascular and renal disease...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825001963 |
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| author | Francesco Buonfiglio Elsa Wilma Böhm Qi Tang Andreas Daiber Adrian Gericke |
| author_facet | Francesco Buonfiglio Elsa Wilma Böhm Qi Tang Andreas Daiber Adrian Gericke |
| author_sort | Francesco Buonfiglio |
| collection | DOAJ |
| description | The renin-angiotensin-aldosterone system (RAAS) plays a fundamental role in regulating blood pressure and fluid homeostasis through key effectors such as angiotensin II and aldosterone. These agents and their receptors have become crucial molecular targets in several cardiovascular and renal diseases. Over the past few decades, a growing body of evidence has revealed the presence of RAAS components in ocular structures, suggesting a tissue-specific RAAS within the eye. Building on this knowledge, studies have indicated that the ocular RAAS plays a significant role in the pathogenesis of various eye diseases. An impaired and overactivated RAAS contributes to the development of severe and widespread disorders affecting both the anterior and posterior segments of the eye. In this context, the current work aims to delve into the pivotal molecular pathways involving the RAAS, with an in-depth exploration of the ocular pathophysiology. It focuses on the relationship between overactivation of the RAAS and oxidative stress, as well as the exacerbation of neovascularization and inflammatory processes. The objective is to provide an updated and comprehensive understanding of the role of the RAAS in ophthalmological diseases, highlighting the therapeutic potential of RAAS modulators and discussing the controversies and challenges in this area of research. |
| format | Article |
| id | doaj-art-bccb4774642443e49632fa225f2fe1cb |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-bccb4774642443e49632fa225f2fe1cb2025-08-20T03:25:59ZengElsevierPharmacological Research1096-11862025-06-0121610777110.1016/j.phrs.2025.107771Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targetsFrancesco Buonfiglio0Elsa Wilma Böhm1Qi Tang2Andreas Daiber3Adrian Gericke4Department of Ophthalmology, University Medical Center of the Johannes Gutenberg, University, Langenbeckstr.1, Mainz 55131, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg, University, Langenbeckstr.1, Mainz 55131, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg, University, Langenbeckstr.1, Mainz 55131, GermanyDepartment of Cardiology I, University Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz 55131, GermanyDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg, University, Langenbeckstr.1, Mainz 55131, Germany; Correspondence to: University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstr. 1, Mainz 55131, Germany.The renin-angiotensin-aldosterone system (RAAS) plays a fundamental role in regulating blood pressure and fluid homeostasis through key effectors such as angiotensin II and aldosterone. These agents and their receptors have become crucial molecular targets in several cardiovascular and renal diseases. Over the past few decades, a growing body of evidence has revealed the presence of RAAS components in ocular structures, suggesting a tissue-specific RAAS within the eye. Building on this knowledge, studies have indicated that the ocular RAAS plays a significant role in the pathogenesis of various eye diseases. An impaired and overactivated RAAS contributes to the development of severe and widespread disorders affecting both the anterior and posterior segments of the eye. In this context, the current work aims to delve into the pivotal molecular pathways involving the RAAS, with an in-depth exploration of the ocular pathophysiology. It focuses on the relationship between overactivation of the RAAS and oxidative stress, as well as the exacerbation of neovascularization and inflammatory processes. The objective is to provide an updated and comprehensive understanding of the role of the RAAS in ophthalmological diseases, highlighting the therapeutic potential of RAAS modulators and discussing the controversies and challenges in this area of research.http://www.sciencedirect.com/science/article/pii/S1043661825001963Renin-angiotensin-aldosterone systemEyePathophysiologySignaling pathwayPharmacological target |
| spellingShingle | Francesco Buonfiglio Elsa Wilma Böhm Qi Tang Andreas Daiber Adrian Gericke Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets Pharmacological Research Renin-angiotensin-aldosterone system Eye Pathophysiology Signaling pathway Pharmacological target |
| title | Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets |
| title_full | Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets |
| title_fullStr | Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets |
| title_full_unstemmed | Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets |
| title_short | Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets |
| title_sort | revisiting the renin angiotensin aldosterone system in the eye mechanistic insights and pharmacological targets |
| topic | Renin-angiotensin-aldosterone system Eye Pathophysiology Signaling pathway Pharmacological target |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825001963 |
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