The role of NF-κB in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. Several transcription factors intricately participate in the initiation and progr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | All Life |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/26895293.2024.2397402 |
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| Summary: | Diabetic cardiomyopathy (DCM), a major risk factor contributing to diabetes-related morbidity and mortality, manifests as a pathophysiologic condition in humans independently of coronary artery disease or hypertension. Several transcription factors intricately participate in the initiation and progression of associated processes. Among these, nuclear factor kappa B (NF-κB), a pleiotropic transcription factor, assumes a crucial role in regulating oxidative stress, inflammatory response, endothelial dysfunction, myocardial fibrosis and hypertrophy, and cardiomyocyte apoptosis in DCM. However, the precise role of NF-κB in DCM remains a subject of ongoing investigation. This article provides a comprehensive review of NF-κB's involvement in several processes associated with DCM. |
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| ISSN: | 2689-5307 |