Do Headache Pain Intensity and Headache Days Influence Psychiatric Comorbidities in Patients with Migraine?
Background : Many psychiatric conditions co-occur with migraine. This study examined whether headache pain intensity and the frequency of monthly headache days (MHD) influence the occurrence of comorbid psychiatric conditions. Methods : A prospective multi-center study was conducted using the valida...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of Pain, Korean Pain Intervention Society
2025-06-01
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| Series: | International Journal of Pain |
| Subjects: | |
| Online Access: | http://painresearch.or.kr/journal/view.html?doi=10.56718/ijp.25-001 |
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| Summary: | Background : Many psychiatric conditions co-occur with migraine. This study examined whether headache pain intensity and the frequency of monthly headache days (MHD) influence the occurrence of comorbid psychiatric conditions. Methods : A prospective multi-center study was conducted using the validated AMPP diagnostic module questionnaire. Headache pain intensity and MHD frequency were assessed in the migraine cohort. A binomial logistic regression model was used to compare psychiatric comorbidities between migraineurs and controls, with odds ratios (OR) and confidence intervals calculated after adjusting for gender, marital status, ethnicity, race, employment status, and family income. Results : After exclusion, 136 individuals with migraines were compared to 168 controls. Adjusted logistic regression analysis indicated that participants with migraines had higher odds of experiencing depression (OR = 2.48 [95% CI, 1.94-3.9], P < 0.001) and anxiety (OR = 2 [95% CI, 1.84-3], P < 0.001). A higher frequency of monthly headache days was associated with over three times the odds for comorbid depression (OR = 3.2 [95% CI, 2.9-4.3], P < 0.001). Increased headache pain intensity was linked to a 1.6-fold increase in the likelihood of anxiety (OR = 1.6 [95% CI, 1.4-2.2], P = 0.020). Conclusions: After adjusting for confounding variables, it was found that individuals with greater headache pain intensity and a higher number of major headache days had significantly increased odds of experiencing anxiety and depression. The subcontinent may exhibit a higher prevalence of psychiatric comorbidities (63.3%) in individuals with migraines compared to developed countries. Factors such as ethnicity, cultural differences, and limited access to mental healthcare facilities may influence the prevalence of psychiatric comorbidities. |
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| ISSN: | 2233-4793 |