Functional Ultrasound Imaging of Auditory Responses in Comatose Patients
Bedside monitoring of brain function in severely brain-injured patients remains a critical clinical challenge. We demonstrate the translational potential of functional ultrasound (fUS) imaging for this purpose. In 6 comatose patients (Glasgow coma scale ≤ 8) with cranial windows after decompressive...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0709 |
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| author | Zihao Chen Na Li Caihua Xi Jiaru He Jiejun Zhu Gang Wu Jinzhao Xia Chunlong Fei Lei Sun Hongzhi Xu Zhihai Qiu |
| author_facet | Zihao Chen Na Li Caihua Xi Jiaru He Jiejun Zhu Gang Wu Jinzhao Xia Chunlong Fei Lei Sun Hongzhi Xu Zhihai Qiu |
| author_sort | Zihao Chen |
| collection | DOAJ |
| description | Bedside monitoring of brain function in severely brain-injured patients remains a critical clinical challenge. We demonstrate the translational potential of functional ultrasound (fUS) imaging for this purpose. In 6 comatose patients (Glasgow coma scale ≤ 8) with cranial windows after decompressive craniectomy, we used a 7.8-MHz transducer optimized for cortical depths of 1.5 to 4 cm to perform real-time fUS during auditory stimulation. We observed task-related increases in regional cerebral blood flow (rCBF) in relevant brain regions (P < 0.001, t test), which correlated with subsequent neurological recovery at 9-month follow-up. These findings establish fUS as a sensitive and portable tool for bedside brain function assessment, offering potential for improved prognostication, treatment guidance, and development of targeted rehabilitative strategies. |
| format | Article |
| id | doaj-art-bcc78ddebbcb4a5a8693c5fd694deada |
| institution | OA Journals |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-bcc78ddebbcb4a5a8693c5fd694deada2025-08-20T01:51:58ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0709Functional Ultrasound Imaging of Auditory Responses in Comatose PatientsZihao Chen0Na Li1Caihua Xi2Jiaru He3Jiejun Zhu4Gang Wu5Jinzhao Xia6Chunlong Fei7Lei Sun8Hongzhi Xu9Zhihai Qiu10Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University; National Center for Neurological Disorders; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Department of Neurosurgery & Neurocritical Care, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University; National Center for Neurological Disorders; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Department of Neurosurgery & Neurocritical Care, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.School of Microelectronics, Xidian University, Xi’an, Shannxi, P. R. China.Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR 999077, P. R. China.Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University; National Center for Neurological Disorders; Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration; Neurosurgical Institute of Fudan University; Shanghai Clinical Medical Center of Neurosurgery; Department of Neurosurgery & Neurocritical Care, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P. R. China.Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong 519031, P. R. China.Bedside monitoring of brain function in severely brain-injured patients remains a critical clinical challenge. We demonstrate the translational potential of functional ultrasound (fUS) imaging for this purpose. In 6 comatose patients (Glasgow coma scale ≤ 8) with cranial windows after decompressive craniectomy, we used a 7.8-MHz transducer optimized for cortical depths of 1.5 to 4 cm to perform real-time fUS during auditory stimulation. We observed task-related increases in regional cerebral blood flow (rCBF) in relevant brain regions (P < 0.001, t test), which correlated with subsequent neurological recovery at 9-month follow-up. These findings establish fUS as a sensitive and portable tool for bedside brain function assessment, offering potential for improved prognostication, treatment guidance, and development of targeted rehabilitative strategies.https://spj.science.org/doi/10.34133/research.0709 |
| spellingShingle | Zihao Chen Na Li Caihua Xi Jiaru He Jiejun Zhu Gang Wu Jinzhao Xia Chunlong Fei Lei Sun Hongzhi Xu Zhihai Qiu Functional Ultrasound Imaging of Auditory Responses in Comatose Patients Research |
| title | Functional Ultrasound Imaging of Auditory Responses in Comatose Patients |
| title_full | Functional Ultrasound Imaging of Auditory Responses in Comatose Patients |
| title_fullStr | Functional Ultrasound Imaging of Auditory Responses in Comatose Patients |
| title_full_unstemmed | Functional Ultrasound Imaging of Auditory Responses in Comatose Patients |
| title_short | Functional Ultrasound Imaging of Auditory Responses in Comatose Patients |
| title_sort | functional ultrasound imaging of auditory responses in comatose patients |
| url | https://spj.science.org/doi/10.34133/research.0709 |
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