HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes

HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes

The control of gluconeogenesis is critical for glucose homeostasis and the pathology of type 2 diabetes (T2D). Here, we uncover a novel function of TET2 in the regulation of gluconeogenesis. In mice, both fasting and a high-fat diet (HFD) stimulate the expression of TET2, and TET2 knockout impairs g...

Full description

Saved in:
Bibliographic Details
Main Authors: Hongchen Li, Xinchao Zhang, Xiaoben Liang, Shuyan Li, Ziyi Cui, Xinyu Zhao, Kai Wang, Bingbing Zha, Haijie Ma, Ming Xu, Lei Lv, Yanping Xu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
TET2
FBP1
HNF4α
gluconeogenesis
diabetes
Online Access:https://elifesciences.org/articles/103663
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items