Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. The National Institute of Aging-Late Onset Alzheimer's Disease Family Study and the National Cell Repository for Alzheimer's Disease conducted a joint genome-wide association study (GWAS) of mult...

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Main Authors: Ellen M Wijsman, Nathan D Pankratz, Yoonha Choi, Joseph H Rothstein, Kelley M Faber, Rong Cheng, Joseph H Lee, Thomas D Bird, David A Bennett, Ramon Diaz-Arrastia, Alison M Goate, Martin Farlow, Bernardino Ghetti, Robert A Sweet, Tatiana M Foroud, Richard Mayeux, NIA-LOAD/NCRAD Family Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001308&type=printable
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