Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region
Background. In cases of tuberculosis in children, contacts with patients with drug-resistant forms are often detected. Treatment and prevention of the disease is based on these data and adherence to treatment. Aims. To analyze the social status of the family of children with tuberculosis, clinical f...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2017-09-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/524 |
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| author | E. Y. Zorkaltseva S. V. Pugacheva A. S. Tolstykh |
| author_facet | E. Y. Zorkaltseva S. V. Pugacheva A. S. Tolstykh |
| author_sort | E. Y. Zorkaltseva |
| collection | DOAJ |
| description | Background. In cases of tuberculosis in children, contacts with patients with drug-resistant forms are often detected. Treatment and prevention of the disease is based on these data and adherence to treatment. Aims. To analyze the social status of the family of children with tuberculosis, clinical forms and drug resistance of MBT in patients who are sources of infection in the outbreak for adequate planning of preventive treatment of contact and treatment of children with tuberculosis. Materials and methods. The study involved 150 children with tuberculosis treated in a hospital in 2009-2012 and 142 children - in 2015-2017. We studied social factors and drug resistance of Mycobacterium tuberculosis in adult patients - sources to child transmission. Drug resistance of MBT cultures was determined by Löwenstein - Jensen medium and automated system BACTEC MGIT 960. Results. 50.0 % of children with tuberculosis are patients of preschool age, 33.0 % of children aged under 3 years. From 2009-2012 to 2015-2017 the proportion of socially disadvantaged families fell from 68.0 % to 45.1 %. At the same time the proportion of children with tuberculosis, contracted from a known contact decreased from 70.0 % to 57.0 %. Often children get infected from mother or from several close relatives (mother, father, grandfather, grandmother), TB patients source of infection of children are often diagnosed with infiltrative (21.9-38.3 %) and fibro-cavernous tuberculosis (17.0-21.0 %). To 2015-2017 multi-drug resistance in the nidi was recorded at 52.2 %. The development of tuberculosis in children was facilitated by the defects of preventative measures: absence of BCG vaccination (from 9.0 to 14.0 % of children), the absence of preventive treatment (55.3-67.5 %). |
| format | Article |
| id | doaj-art-bcc18962a83f486cb18323f43e117c38 |
| institution | Kabale University |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| publishDate | 2017-09-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj-art-bcc18962a83f486cb18323f43e117c382025-08-20T03:56:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962017-09-0125(2)14715010.12737/article_5a3a0eabd5ee12.61732822524Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk regionE. Y. Zorkaltseva0S. V. Pugacheva1A. S. Tolstykh2Irkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional EducationRegional Children’s Tuberculosis HospitalIrkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional EducationBackground. In cases of tuberculosis in children, contacts with patients with drug-resistant forms are often detected. Treatment and prevention of the disease is based on these data and adherence to treatment. Aims. To analyze the social status of the family of children with tuberculosis, clinical forms and drug resistance of MBT in patients who are sources of infection in the outbreak for adequate planning of preventive treatment of contact and treatment of children with tuberculosis. Materials and methods. The study involved 150 children with tuberculosis treated in a hospital in 2009-2012 and 142 children - in 2015-2017. We studied social factors and drug resistance of Mycobacterium tuberculosis in adult patients - sources to child transmission. Drug resistance of MBT cultures was determined by Löwenstein - Jensen medium and automated system BACTEC MGIT 960. Results. 50.0 % of children with tuberculosis are patients of preschool age, 33.0 % of children aged under 3 years. From 2009-2012 to 2015-2017 the proportion of socially disadvantaged families fell from 68.0 % to 45.1 %. At the same time the proportion of children with tuberculosis, contracted from a known contact decreased from 70.0 % to 57.0 %. Often children get infected from mother or from several close relatives (mother, father, grandfather, grandmother), TB patients source of infection of children are often diagnosed with infiltrative (21.9-38.3 %) and fibro-cavernous tuberculosis (17.0-21.0 %). To 2015-2017 multi-drug resistance in the nidi was recorded at 52.2 %. The development of tuberculosis in children was facilitated by the defects of preventative measures: absence of BCG vaccination (from 9.0 to 14.0 % of children), the absence of preventive treatment (55.3-67.5 %).https://www.actabiomedica.ru/jour/article/view/524tuberculosis in childrendrug resistance of mycobacterium tuberculosissocial factors |
| spellingShingle | E. Y. Zorkaltseva S. V. Pugacheva A. S. Tolstykh Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region Acta Biomedica Scientifica tuberculosis in children drug resistance of mycobacterium tuberculosis social factors |
| title | Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region |
| title_full | Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region |
| title_fullStr | Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region |
| title_full_unstemmed | Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region |
| title_short | Medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the Irkutsk region |
| title_sort | medical and social characteristics of children with tuberculosis in conditions of social insufficiency in the irkutsk region |
| topic | tuberculosis in children drug resistance of mycobacterium tuberculosis social factors |
| url | https://www.actabiomedica.ru/jour/article/view/524 |
| work_keys_str_mv | AT eyzorkaltseva medicalandsocialcharacteristicsofchildrenwithtuberculosisinconditionsofsocialinsufficiencyintheirkutskregion AT svpugacheva medicalandsocialcharacteristicsofchildrenwithtuberculosisinconditionsofsocialinsufficiencyintheirkutskregion AT astolstykh medicalandsocialcharacteristicsofchildrenwithtuberculosisinconditionsofsocialinsufficiencyintheirkutskregion |