Diarrhea in peripheral stem cell transplant recipients: a developing country’s experience
Introduction: We aimed to determine the frequency and microbiological causes of diarrhea occurring during the first 100 days in allogeneic (allo-) and autologous (auto-) stem cell transplantation (SCT) patients. Methodology: A total of 452 patients who underwent transplantation due to hematological...
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The Journal of Infection in Developing Countries
2014-05-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/3602 |
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| author | Cigdem Pala Leylagul Kaynar Ruksan Buyukoglan Fatih Kurnaz Gokhan Metan Suleyman Yazar Suleyman Durmaz Ayse Sakioglu Sedar Sivgin Bulent Eser Ali Unal Mustafa Cetin |
| author_facet | Cigdem Pala Leylagul Kaynar Ruksan Buyukoglan Fatih Kurnaz Gokhan Metan Suleyman Yazar Suleyman Durmaz Ayse Sakioglu Sedar Sivgin Bulent Eser Ali Unal Mustafa Cetin |
| author_sort | Cigdem Pala |
| collection | DOAJ |
| description | Introduction: We aimed to determine the frequency and microbiological causes of diarrhea occurring during the first 100 days in allogeneic (allo-) and autologous (auto-) stem cell transplantation (SCT) patients.
Methodology: A total of 452 patients who underwent transplantation due to hematological or solid organ malignancy were included. From the administration of the conditioning regimen up to day 100 post-transplant, diarrhea cases lasting at least three days with a minimum of three episodes per day were evaluated.
Results: Cases of diarrhea were observed in 94 patients out of 227 subjects who received allo-SCT and in 107 patients out of 225 who received auto-SCT. The incidence rate of diarrhea in both patients undergoing autologous and allogeneic transplant was 47.5% and 41.4%, respectively. The cause of the diarrhea could be detected in 20.5% of auto-SCT patients and in 30.8% of allo-SCT patients. Parasitic infections were frequently observed in both autologous and allogeneic transplant patients in the first 20 days. In the late period, significantly more patients developed diarrhea in the allo-SCT recipient group than in the auto-SCT recipients due to graft versus host disease (GVHD) and cytomegalovirus (CMV) colitis.
Conclusions: This study revealed the causes of diarrhea and the prevalence and factors of parasitic infections in transplant patients in Turkey. All causative factors of diarrhea should be considered in detail, feces analyses should be evaluated for each patient, and endoscopic biopsy samples should be obtained when required in immunosuppressive patients undergoing stem cell transplantation.
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| format | Article |
| id | doaj-art-bcbea5c5af46413a8608a5bd48b21676 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2014-05-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-bcbea5c5af46413a8608a5bd48b216762025-08-20T02:57:04ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802014-05-0180510.3855/jidc.3602Diarrhea in peripheral stem cell transplant recipients: a developing country’s experienceCigdem Pala0Leylagul Kaynar1Ruksan Buyukoglan2Fatih Kurnaz3Gokhan Metan4Suleyman Yazar5Suleyman Durmaz6Ayse Sakioglu7Sedar Sivgin8Bulent Eser9Ali Unal10Mustafa Cetin11Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, KayseriErciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, KayseriErciyes University, Faculty of Medicine, Department of Genetic, KayseriHarran University, Faculty of Medicine, Department of Hematology, ŞanlıurfaErciyes University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, KayseriErciyes University, Faculty of Medicine, Department of parasitology, KayseriMicrobiology Laboratory, Goverment Hospital of Düzici, Osmaniye - TURKEYKızılay Blood Centre, KayseriErciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, KayseriErciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, KayseriErciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, KayseriErciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, KayseriIntroduction: We aimed to determine the frequency and microbiological causes of diarrhea occurring during the first 100 days in allogeneic (allo-) and autologous (auto-) stem cell transplantation (SCT) patients. Methodology: A total of 452 patients who underwent transplantation due to hematological or solid organ malignancy were included. From the administration of the conditioning regimen up to day 100 post-transplant, diarrhea cases lasting at least three days with a minimum of three episodes per day were evaluated. Results: Cases of diarrhea were observed in 94 patients out of 227 subjects who received allo-SCT and in 107 patients out of 225 who received auto-SCT. The incidence rate of diarrhea in both patients undergoing autologous and allogeneic transplant was 47.5% and 41.4%, respectively. The cause of the diarrhea could be detected in 20.5% of auto-SCT patients and in 30.8% of allo-SCT patients. Parasitic infections were frequently observed in both autologous and allogeneic transplant patients in the first 20 days. In the late period, significantly more patients developed diarrhea in the allo-SCT recipient group than in the auto-SCT recipients due to graft versus host disease (GVHD) and cytomegalovirus (CMV) colitis. Conclusions: This study revealed the causes of diarrhea and the prevalence and factors of parasitic infections in transplant patients in Turkey. All causative factors of diarrhea should be considered in detail, feces analyses should be evaluated for each patient, and endoscopic biopsy samples should be obtained when required in immunosuppressive patients undergoing stem cell transplantation. https://jidc.org/index.php/journal/article/view/3602diarrheastem cell transplantationmicrobiological causes |
| spellingShingle | Cigdem Pala Leylagul Kaynar Ruksan Buyukoglan Fatih Kurnaz Gokhan Metan Suleyman Yazar Suleyman Durmaz Ayse Sakioglu Sedar Sivgin Bulent Eser Ali Unal Mustafa Cetin Diarrhea in peripheral stem cell transplant recipients: a developing country’s experience Journal of Infection in Developing Countries diarrhea stem cell transplantation microbiological causes |
| title | Diarrhea in peripheral stem cell transplant recipients: a developing country’s experience |
| title_full | Diarrhea in peripheral stem cell transplant recipients: a developing country’s experience |
| title_fullStr | Diarrhea in peripheral stem cell transplant recipients: a developing country’s experience |
| title_full_unstemmed | Diarrhea in peripheral stem cell transplant recipients: a developing country’s experience |
| title_short | Diarrhea in peripheral stem cell transplant recipients: a developing country’s experience |
| title_sort | diarrhea in peripheral stem cell transplant recipients a developing country s experience |
| topic | diarrhea stem cell transplantation microbiological causes |
| url | https://jidc.org/index.php/journal/article/view/3602 |
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