A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic TransitionSummary

A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic TransitionSummary

Background & Aims: GATA family transcription factors are somatically variable (SV) in esophageal adenocarcinomas (EAC) and inducible by simulated reflux. Our study examines the mechanisms whereby GATA family members (GATA4, GATA6, and the atypical TRPS-1) influence oncogenesis during the Bar...

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Bibliographic Details
Main Authors: Omar Abuhussein, Sara Hosseini-Farahabadi, Corina Stewart, Stephane Flibotte, Alireza Heravi-Moussavi, David Farnell, David Schaeffer, Fergal Donnellan, Frank McKeon, Wa Xian, Dermot Kelleher, Shane Patrick Duggan
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
High-Grade Dysplasia
Esophageal Adenocarcinoma
Gastroesophageal Reflux Disease
Organ-On-A-Chip
Barrett’s Esophagus
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25000931
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