Combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancer
BackgroundAccurately identifying the status of lymph node metastasis (LNM) is crucial for determining the appropriate treatment strategy for early gastric cancer (EGC) patients.MethodsUnivariate and multivariate logistic regression analyses were used to explore the association between clinicopatholo...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1533889/full |
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| _version_ | 1849313505423917056 |
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| author | Yujian He Xiaoli Xie Bingxue Yang Xiaoxu Jin Zhijie Feng |
| author_facet | Yujian He Xiaoli Xie Bingxue Yang Xiaoxu Jin Zhijie Feng |
| author_sort | Yujian He |
| collection | DOAJ |
| description | BackgroundAccurately identifying the status of lymph node metastasis (LNM) is crucial for determining the appropriate treatment strategy for early gastric cancer (EGC) patients.MethodsUnivariate and multivariate logistic regression analyses were used to explore the association between clinicopathological factors and LNM in EGC patients, leading to the development of a nomogram. Differential expression analysis was conducted to identify biomarkers associated with LNM, and their expression was evaluated through immunohistochemistry. The biomarker was integrated into the conventional model to create a new model, which was then assessed for reclassification and discrimination abilities.ResultsMultivariate logistic regression analysis revealed that tumor size, histological type, and the presence of ulcers are independent risk factors for LNM in EGC patients. The nomogram demonstrated good clinical performance. Incorporating HAVCR1 immunohistochemical expression into the new model further improved its performance, reclassification, and discrimination abilities.ConclusionThe novel nomogram predictive model, based on preoperative clinicopathological factors such as tumor size, histological type, presence of ulcers, and HAVCR1 expression, provides valuable guidance for selecting treatment strategies for EGC patients. |
| format | Article |
| id | doaj-art-bcbcf31bbf224e7fb27065254e318826 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-bcbcf31bbf224e7fb27065254e3188262025-08-20T03:52:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-05-011510.3389/fonc.2025.15338891533889Combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancerYujian HeXiaoli XieBingxue YangXiaoxu JinZhijie FengBackgroundAccurately identifying the status of lymph node metastasis (LNM) is crucial for determining the appropriate treatment strategy for early gastric cancer (EGC) patients.MethodsUnivariate and multivariate logistic regression analyses were used to explore the association between clinicopathological factors and LNM in EGC patients, leading to the development of a nomogram. Differential expression analysis was conducted to identify biomarkers associated with LNM, and their expression was evaluated through immunohistochemistry. The biomarker was integrated into the conventional model to create a new model, which was then assessed for reclassification and discrimination abilities.ResultsMultivariate logistic regression analysis revealed that tumor size, histological type, and the presence of ulcers are independent risk factors for LNM in EGC patients. The nomogram demonstrated good clinical performance. Incorporating HAVCR1 immunohistochemical expression into the new model further improved its performance, reclassification, and discrimination abilities.ConclusionThe novel nomogram predictive model, based on preoperative clinicopathological factors such as tumor size, histological type, presence of ulcers, and HAVCR1 expression, provides valuable guidance for selecting treatment strategies for EGC patients.https://www.frontiersin.org/articles/10.3389/fonc.2025.1533889/fullearly gastric cancerlymph node metastasisnomogramHAVCR1predictive model |
| spellingShingle | Yujian He Xiaoli Xie Bingxue Yang Xiaoxu Jin Zhijie Feng Combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancer Frontiers in Oncology early gastric cancer lymph node metastasis nomogram HAVCR1 predictive model |
| title | Combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancer |
| title_full | Combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancer |
| title_fullStr | Combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancer |
| title_full_unstemmed | Combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancer |
| title_short | Combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancer |
| title_sort | combining biomarkers to construct a novel predictive model for predicting preoperative lymph node metastasis in early gastric cancer |
| topic | early gastric cancer lymph node metastasis nomogram HAVCR1 predictive model |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1533889/full |
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