Mitotherapy attenuates sepsis-induced brain injury in rats subjected to cecal ligation and puncture: Role of SIRT-1/PGC-1α network

Mitotherapy attenuates sepsis-induced brain injury in rats subjected to cecal ligation and puncture: Role of SIRT-1/PGC-1α network

Objective(s): Sepsis-induced brain injury poses a critical challenge with limited therapeutic options. Mitochondrial dysfunction is a central contributor to this pathogenesis. The current work aimed to examine the effects of mitochondrial transplantation, termed “mitotherapy”, on sepsis-induced brai...

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Bibliographic Details
Main Authors: Behnaz Mokhtari, Alireza Alihemmati, Soleyman Bafadam, Solmaz Boraghi, Reza Badalzadeh, Ata Mahmoodpoor
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2025-08-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
brain
mitochondria
mitotherapy
neuroprotection
sepsis
Online Access:https://ijbms.mums.ac.ir/article_25994_b3f6ac56189cf53304d2d1235e77f2d9.pdf
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