Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery
Improving outcomes after stroke depends on understanding both the causes of initial function/impairment and the mechanisms of recovery. Recovery in patients with initially low function/high impairment is variable, suggesting the factors relating to initial function/impairment are different to the fa...
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Elsevier
2025-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158225000245 |
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| author | Catharina Zich Nick S. Ward Nina Forss Sven Bestmann Andrew J. Quinn Eeva Karhunen Kristina Laaksonen |
| author_facet | Catharina Zich Nick S. Ward Nina Forss Sven Bestmann Andrew J. Quinn Eeva Karhunen Kristina Laaksonen |
| author_sort | Catharina Zich |
| collection | DOAJ |
| description | Improving outcomes after stroke depends on understanding both the causes of initial function/impairment and the mechanisms of recovery. Recovery in patients with initially low function/high impairment is variable, suggesting the factors relating to initial function/impairment are different to the factors important for subsequent recovery. Here we aimed to determine the contribution of altered brain structure and function to initial severity and subsequent recovery of the upper limb post-stroke.The Nine-Hole Peg Test was recorded in week 1 and one-month post-stroke and used to divide 36 stroke patients (18 females, age: M = 66.56 years) into those with high/low initial function and high/low subsequent recovery. We determined differences in week 1 brain structure (Magnetic Resonance Imaging) and function (Magnetoencephalography, tactile stimulation) between high/low patients for both initial function and subsequent recovery. Lastly, we examined the relative contribution of changes in brain structure and function to recovery in patients with low levels of initial function.Low initial function and low subsequent recovery are related to lower sensorimotor β power and greater lesion-induced disconnection of contralateral [ipsilesional] white-matter motor projection connections. Moreover, differences in intra-hemispheric connectivity (structural and functional) are unique to initial motor function, while differences in inter-hemispheric connectivity (structural and functional) are unique to subsequent motor recovery.Function-related and recovery-related differences in brain function and structure after stroke are related, yet not identical. Separating out the factors that contribute to each process is key to identifying potential therapeutic targets for improving outcomes. |
| format | Article |
| id | doaj-art-bcb0f2f20eea44a58ec884ce07fa4023 |
| institution | OA Journals |
| issn | 2213-1582 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-bcb0f2f20eea44a58ec884ce07fa40232025-08-20T02:06:20ZengElsevierNeuroImage: Clinical2213-15822025-01-014510375410.1016/j.nicl.2025.103754Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recoveryCatharina Zich0Nick S. Ward1Nina Forss2Sven Bestmann3Andrew J. Quinn4Eeva Karhunen5Kristina Laaksonen6Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, United Kingdom; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Medical Research Council Brain Network Dynamics Unit, University of Oxford, United Kingdom; Corresponding author at: Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, 33 Queen Square, 3rd floor, Box 146, London WC1N 3BG, United Kingdom.Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, United KingdomDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland; Neurocenter, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, FinlandDepartment of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, United Kingdom; Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, United KingdomCentre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, United KingdomDepartment of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland; Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, FinlandImproving outcomes after stroke depends on understanding both the causes of initial function/impairment and the mechanisms of recovery. Recovery in patients with initially low function/high impairment is variable, suggesting the factors relating to initial function/impairment are different to the factors important for subsequent recovery. Here we aimed to determine the contribution of altered brain structure and function to initial severity and subsequent recovery of the upper limb post-stroke.The Nine-Hole Peg Test was recorded in week 1 and one-month post-stroke and used to divide 36 stroke patients (18 females, age: M = 66.56 years) into those with high/low initial function and high/low subsequent recovery. We determined differences in week 1 brain structure (Magnetic Resonance Imaging) and function (Magnetoencephalography, tactile stimulation) between high/low patients for both initial function and subsequent recovery. Lastly, we examined the relative contribution of changes in brain structure and function to recovery in patients with low levels of initial function.Low initial function and low subsequent recovery are related to lower sensorimotor β power and greater lesion-induced disconnection of contralateral [ipsilesional] white-matter motor projection connections. Moreover, differences in intra-hemispheric connectivity (structural and functional) are unique to initial motor function, while differences in inter-hemispheric connectivity (structural and functional) are unique to subsequent motor recovery.Function-related and recovery-related differences in brain function and structure after stroke are related, yet not identical. Separating out the factors that contribute to each process is key to identifying potential therapeutic targets for improving outcomes.http://www.sciencedirect.com/science/article/pii/S2213158225000245Acute strokeMEGMRIRecoverySensorimotor system |
| spellingShingle | Catharina Zich Nick S. Ward Nina Forss Sven Bestmann Andrew J. Quinn Eeva Karhunen Kristina Laaksonen Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery NeuroImage: Clinical Acute stroke MEG MRI Recovery Sensorimotor system |
| title | Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery |
| title_full | Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery |
| title_fullStr | Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery |
| title_full_unstemmed | Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery |
| title_short | Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery |
| title_sort | post stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery |
| topic | Acute stroke MEG MRI Recovery Sensorimotor system |
| url | http://www.sciencedirect.com/science/article/pii/S2213158225000245 |
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