Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts
Cardiovascular disease is one of the leading causes of death and serious illness in Europe and worldwide. Conventional treatment—replacing the damaged blood vessel with an autologous graft—is not always affordable for the patient, so alternative approaches are being sought. One such approach is pati...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/11/1/4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588438758490112 |
|---|---|
| author | Jana Matějková Denisa Kaňoková Roman Matějka |
| author_facet | Jana Matějková Denisa Kaňoková Roman Matějka |
| author_sort | Jana Matějková |
| collection | DOAJ |
| description | Cardiovascular disease is one of the leading causes of death and serious illness in Europe and worldwide. Conventional treatment—replacing the damaged blood vessel with an autologous graft—is not always affordable for the patient, so alternative approaches are being sought. One such approach is patient-specific tissue bioprinting, which allows for precise distribution of cells, material, and biochemical signals. With further developmental support, a functional replacement tissue or vessel can be created. This review provides an overview of the current state of bioprinting for vascular graft manufacturing and summarizes the hydrogels used as bioinks, the material of carriers, and the current methods of fabrication used, especially for vessels smaller than 6 mm, which are the most challenging for cardiovascular replacements. The fabrication methods are divided into several sections—self-supporting grafts based on simple 3D bioprinting and bioprinting of bioinks on scaffolds made of decellularized or nanofibrous material. |
| format | Article |
| id | doaj-art-bcb08168fe6f49238284bd8a9be42464 |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-bcb08168fe6f49238284bd8a9be424642025-01-24T13:33:44ZengMDPI AGGels2310-28612024-12-01111410.3390/gels11010004Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular GraftsJana Matějková0Denisa Kaňoková1Roman Matějka2Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, 27201 Kladno, Czech RepublicDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, 27201 Kladno, Czech RepublicDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, 27201 Kladno, Czech RepublicCardiovascular disease is one of the leading causes of death and serious illness in Europe and worldwide. Conventional treatment—replacing the damaged blood vessel with an autologous graft—is not always affordable for the patient, so alternative approaches are being sought. One such approach is patient-specific tissue bioprinting, which allows for precise distribution of cells, material, and biochemical signals. With further developmental support, a functional replacement tissue or vessel can be created. This review provides an overview of the current state of bioprinting for vascular graft manufacturing and summarizes the hydrogels used as bioinks, the material of carriers, and the current methods of fabrication used, especially for vessels smaller than 6 mm, which are the most challenging for cardiovascular replacements. The fabrication methods are divided into several sections—self-supporting grafts based on simple 3D bioprinting and bioprinting of bioinks on scaffolds made of decellularized or nanofibrous material.https://www.mdpi.com/2310-2861/11/1/4bioprintingvascular graftstissue-engineered vascular graftsextrusion bioprintinginkjet bioprintingdecellularized scaffold |
| spellingShingle | Jana Matějková Denisa Kaňoková Roman Matějka Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts Gels bioprinting vascular grafts tissue-engineered vascular grafts extrusion bioprinting inkjet bioprinting decellularized scaffold |
| title | Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts |
| title_full | Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts |
| title_fullStr | Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts |
| title_full_unstemmed | Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts |
| title_short | Current Status of Bioprinting Using Polymer Hydrogels for the Production of Vascular Grafts |
| title_sort | current status of bioprinting using polymer hydrogels for the production of vascular grafts |
| topic | bioprinting vascular grafts tissue-engineered vascular grafts extrusion bioprinting inkjet bioprinting decellularized scaffold |
| url | https://www.mdpi.com/2310-2861/11/1/4 |
| work_keys_str_mv | AT janamatejkova currentstatusofbioprintingusingpolymerhydrogelsfortheproductionofvasculargrafts AT denisakanokova currentstatusofbioprintingusingpolymerhydrogelsfortheproductionofvasculargrafts AT romanmatejka currentstatusofbioprintingusingpolymerhydrogelsfortheproductionofvasculargrafts |