Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up study
Patients with systemic lupus erythematosus (SLE) have a higher incidence of tuberculosis (TB)infection compared to the general healthy population. The use of glucocorticoids and immunosuppressive agents for SLE management further elevates TB risk. This study aimed to evaluate the prevalence of laten...
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Elsevier
2025-08-01
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| Series: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405579425000440 |
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| author | Yiling Zhang Gengmin Zhou Hongli Wang Qingwen Wang Guofang Deng |
| author_facet | Yiling Zhang Gengmin Zhou Hongli Wang Qingwen Wang Guofang Deng |
| author_sort | Yiling Zhang |
| collection | DOAJ |
| description | Patients with systemic lupus erythematosus (SLE) have a higher incidence of tuberculosis (TB)infection compared to the general healthy population. The use of glucocorticoids and immunosuppressive agents for SLE management further elevates TB risk. This study aimed to evaluate the prevalence of latent tuberculosis infection (LTBI) in SLE patients and explore risk factors for progression to active TB (ATB) in those with concurrent SLE and LTBI. We conducted a retrospective analysis of SLE patients treated at the Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, between 2014 and 2023. During a five − year follow − up period, LTBI was detected in 122 patients (24.11%). Of these, 11 individuals (all from the subgroup of 108 patients who did not receive tuberculosis preventive treatment [TPT]) progressed to ATB. A comparative analysis between the 11 ATB cases and 111 non-progressing LTBI patients revealed significant differences: ATB cases showed higher cyclophosphamide (CTX) usage, elevated high-sensitivity C-reactive protein (hs-CRP) levels, and less frequent hydroxychloroquine (HCQ)administration. These findings underscore the need for regular monitoring during prolonged CTX therapy, especially in moderate-to-high TB burden regions, and highlight the potential protective role of HCQ. |
| format | Article |
| id | doaj-art-bcb05606b6764ed599a429d1dffb3062 |
| institution | Kabale University |
| issn | 2405-5794 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| spelling | doaj-art-bcb05606b6764ed599a429d1dffb30622025-08-20T03:58:00ZengElsevierJournal of Clinical Tuberculosis and Other Mycobacterial Diseases2405-57942025-08-014010055310.1016/j.jctube.2025.100553Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up studyYiling Zhang0Gengmin Zhou1Hongli Wang2Qingwen Wang3Guofang Deng4Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen, Guangdong, ChinaDepartment of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen, Guangdong, ChinaDepartment of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen, Guangdong, ChinaDepartment of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen, Guangdong, China; Corresponding authors at: Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen, Guangdong, China.Corresponding authors at: Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen, Guangdong, China.; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen, Guangdong, China; Division Two of Pulmonary Diseases Department, Shenzhen Third People's Hospital, China; National Clinical Research Center for Infectious Disease (Shenzhen), China; Southern University of Science and Technology, Shenzhen 518112, ChinaPatients with systemic lupus erythematosus (SLE) have a higher incidence of tuberculosis (TB)infection compared to the general healthy population. The use of glucocorticoids and immunosuppressive agents for SLE management further elevates TB risk. This study aimed to evaluate the prevalence of latent tuberculosis infection (LTBI) in SLE patients and explore risk factors for progression to active TB (ATB) in those with concurrent SLE and LTBI. We conducted a retrospective analysis of SLE patients treated at the Department of Rheumatology and Immunology, Peking University Shenzhen Hospital, between 2014 and 2023. During a five − year follow − up period, LTBI was detected in 122 patients (24.11%). Of these, 11 individuals (all from the subgroup of 108 patients who did not receive tuberculosis preventive treatment [TPT]) progressed to ATB. A comparative analysis between the 11 ATB cases and 111 non-progressing LTBI patients revealed significant differences: ATB cases showed higher cyclophosphamide (CTX) usage, elevated high-sensitivity C-reactive protein (hs-CRP) levels, and less frequent hydroxychloroquine (HCQ)administration. These findings underscore the need for regular monitoring during prolonged CTX therapy, especially in moderate-to-high TB burden regions, and highlight the potential protective role of HCQ.http://www.sciencedirect.com/science/article/pii/S2405579425000440Co-infectionSystemic lupus erythematosusLatent tuberculosis infectionRisk factorsRetrospective study |
| spellingShingle | Yiling Zhang Gengmin Zhou Hongli Wang Qingwen Wang Guofang Deng Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up study Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Co-infection Systemic lupus erythematosus Latent tuberculosis infection Risk factors Retrospective study |
| title | Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up study |
| title_full | Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up study |
| title_fullStr | Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up study |
| title_full_unstemmed | Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up study |
| title_short | Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up study |
| title_sort | retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection a 5 year follow up study |
| topic | Co-infection Systemic lupus erythematosus Latent tuberculosis infection Risk factors Retrospective study |
| url | http://www.sciencedirect.com/science/article/pii/S2405579425000440 |
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