Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations
While genetic studies have provided insights into essential hypertension (EH, defined by high blood pressure ≥140/90 mmHg), investigation through epigenetics may address gaps in understanding its heritability. This study focused on African Brazilian populations in Vale do Ribeira River region, due t...
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Taylor & Francis Group
2025-12-01
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| Series: | Epigenetics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2025.2477850 |
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| author | Camila Cristina Avila Martins Mariana Maschietto Lilian Kimura Lucas Alvizi Kelly Nunes Vinícius Magalhães Borges Ana Cristina Victorino Krepischi Regina Célia Mingroni-Netto |
| author_facet | Camila Cristina Avila Martins Mariana Maschietto Lilian Kimura Lucas Alvizi Kelly Nunes Vinícius Magalhães Borges Ana Cristina Victorino Krepischi Regina Célia Mingroni-Netto |
| author_sort | Camila Cristina Avila Martins |
| collection | DOAJ |
| description | While genetic studies have provided insights into essential hypertension (EH, defined by high blood pressure ≥140/90 mmHg), investigation through epigenetics may address gaps in understanding its heritability. This study focused on African Brazilian populations in Vale do Ribeira River region, due to their high hypertension prevalence. We aimed to determine if DNA methylation is linked to hypertension susceptibility, through a genome-wide evaluation of 80 peripheral blood samples from normotensive (39) and hypertensive (41) individuals, with Infinium Methylation EPIC BeadChip platform. Data were analyzed using ChAMP package and cross-referenced with information from databases such as EWAS Atlas, GWAS catalog, GeneCards, literature, and tools such as VarElect and EWAS Toolkit. The comparison between hypertensive and normotensive revealed 190 differentially methylated CpG positions (DMPs) and 46 differentially methylated regions (DMRs), both with p-value ≤0.05. Among the DMPs, 27 were found to have a plausible role in blood pressure. Among the DMRs, those mapped to ABAT, BLCAP, CERS3, EIF4E, FMN1, GABBR1, HLA-DQB2, HOXA5, IL5RA, KCNH2, MIR487B, MIR539, MIR886, MKRN3, NUDT12, PON3, RNF39, RWDD3, and TSHBS1 were highlighted because of their lowest p-values, current literature, and/or VarElect prioritization. Our findings suggest that differences in methylation contribute to the high susceptibility to essential hypertension in these populations. |
| format | Article |
| id | doaj-art-bcae33d964144ffdb1449af5d8032ad9 |
| institution | DOAJ |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-bcae33d964144ffdb1449af5d8032ad92025-08-20T02:48:24ZengTaylor & Francis GroupEpigenetics1559-22941559-23082025-12-0120110.1080/15592294.2025.2477850Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populationsCamila Cristina Avila Martins0Mariana Maschietto1Lilian Kimura2Lucas Alvizi3Kelly Nunes4Vinícius Magalhães Borges5Ana Cristina Victorino Krepischi6Regina Célia Mingroni-Netto7Centro de Estudos sobre o Genoma Humano e Células Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, BrazilResearch Center, Boldrini Children’s Center, Campinas, BrazilCentro de Estudos sobre o Genoma Humano e Células Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, BrazilCell & Development Biology, University College London, London, UKCentro de Estudos sobre o Genoma Humano e Células Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, BrazilCentro de Estudos sobre o Genoma Humano e Células Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, BrazilCentro de Estudos sobre o Genoma Humano e Células Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, BrazilCentro de Estudos sobre o Genoma Humano e Células Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, BrazilWhile genetic studies have provided insights into essential hypertension (EH, defined by high blood pressure ≥140/90 mmHg), investigation through epigenetics may address gaps in understanding its heritability. This study focused on African Brazilian populations in Vale do Ribeira River region, due to their high hypertension prevalence. We aimed to determine if DNA methylation is linked to hypertension susceptibility, through a genome-wide evaluation of 80 peripheral blood samples from normotensive (39) and hypertensive (41) individuals, with Infinium Methylation EPIC BeadChip platform. Data were analyzed using ChAMP package and cross-referenced with information from databases such as EWAS Atlas, GWAS catalog, GeneCards, literature, and tools such as VarElect and EWAS Toolkit. The comparison between hypertensive and normotensive revealed 190 differentially methylated CpG positions (DMPs) and 46 differentially methylated regions (DMRs), both with p-value ≤0.05. Among the DMPs, 27 were found to have a plausible role in blood pressure. Among the DMRs, those mapped to ABAT, BLCAP, CERS3, EIF4E, FMN1, GABBR1, HLA-DQB2, HOXA5, IL5RA, KCNH2, MIR487B, MIR539, MIR886, MKRN3, NUDT12, PON3, RNF39, RWDD3, and TSHBS1 were highlighted because of their lowest p-values, current literature, and/or VarElect prioritization. Our findings suggest that differences in methylation contribute to the high susceptibility to essential hypertension in these populations.https://www.tandfonline.com/doi/10.1080/15592294.2025.2477850DNA methylationessential hypertensionQuilombo populationscardiac epigenetics |
| spellingShingle | Camila Cristina Avila Martins Mariana Maschietto Lilian Kimura Lucas Alvizi Kelly Nunes Vinícius Magalhães Borges Ana Cristina Victorino Krepischi Regina Célia Mingroni-Netto Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations Epigenetics DNA methylation essential hypertension Quilombo populations cardiac epigenetics |
| title | Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations |
| title_full | Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations |
| title_fullStr | Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations |
| title_full_unstemmed | Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations |
| title_short | Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations |
| title_sort | differential methylation in blood pressure control genes is associated to essential hypertension in african brazilian populations |
| topic | DNA methylation essential hypertension Quilombo populations cardiac epigenetics |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2025.2477850 |
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