Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice

Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice

Abstract Background Elderly individuals face heightened susceptibility to infectious diseases and diminished vaccine responses. Vaccine adjuvants offer a solution. Despite aluminum adjuvant’s long history, its limitations in inducing strong cellular immunity and protecting immunocompromised individu...

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Main Authors: Yue Liu, Man Yang, Meifeng Nie, Shuyu Wu, Rong Su, Dekui Qiu, Shouneng Lu, Hualong Xiong, Jinlei Zhang, Shengxiang Ge, Quan Yuan, Qinjian Zhao, Tianying Zhang, Yingbin Wang, Ningshao Xia
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Immunity & Ageing
Subjects:
Risedronate
Vaccine adjuvant
Aged mice
Immune enhancement
Mechanism
Online Access:https://doi.org/10.1186/s12979-025-00512-0
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