Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice
Preventing disease and maintaining the health of the elderly are crucial goals for an aging population, with obesity and immune function restoration being of paramount importance. Obesity, particularly visceral obesity characterized by excessive fat accumulation around the abdominal organs, is linke...
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Taylor & Francis Group
2024-12-01
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| Series: | Animal Cells and Systems |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2024.2374547 |
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| author | Seul-Ki Mun Chang Joo Jang Semi Jo Si-Hyoun Park Hyun Bo Sim Sonny C. Ramos Hyeongyeong Kim Yu-Jeong Choi Dae-Han Park Kyung-Wuk Park Beom-Gyun Jeong Dae Heon Kim Kyung-Yun Kang Jong-Jin Kim |
| author_facet | Seul-Ki Mun Chang Joo Jang Semi Jo Si-Hyoun Park Hyun Bo Sim Sonny C. Ramos Hyeongyeong Kim Yu-Jeong Choi Dae-Han Park Kyung-Wuk Park Beom-Gyun Jeong Dae Heon Kim Kyung-Yun Kang Jong-Jin Kim |
| author_sort | Seul-Ki Mun |
| collection | DOAJ |
| description | Preventing disease and maintaining the health of the elderly are crucial goals for an aging population, with obesity and immune function restoration being of paramount importance. Obesity, particularly visceral obesity characterized by excessive fat accumulation around the abdominal organs, is linked to chronic conditions such as diabetes, hypertension, cardiovascular diseases, and immune dysfunction. Globally, obesity is considered a disease, prompting significant research interest in its treatment. Therefore, it is essential to explore potential therapeutic and preventive strategies to address obesity and the decline in immune function brought about by aging. Tenebrio molitor larvae (TML), commonly known as ‘mealworms,’ are rich in unsaturated fatty acids, including oleic and linoleic acids, and essential amino acids, such as isoleucine and tyrosine. In this study, we aimed to investigate the effects of the consumption of TML oil and mealworm fermented extract (MWF-1) on obesity and immunological changes in aged obese mice. Our data showed reduced body fat in 23-week-old C57BL/6 mice fed processed TML products for 6 weeks. Additionally, the characteristically high levels of serum triglycerides decreased by treating with TML oil. The immune responsiveness results confirmed an increase in B cells by treating with MWF-1, while cytokine levels (interferon-gamma, tumor necrosis factor-alpha, interleukin-2, and −6) were restored to levels similar to young mice. These results suggest that TML oil and MWF-1 are promising dietary supplements for addressing obesity and restoring immune function. |
| format | Article |
| id | doaj-art-bcaa4cfca2a242ecb65b0f1beb1db1a9 |
| institution | DOAJ |
| issn | 1976-8354 2151-2485 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj-art-bcaa4cfca2a242ecb65b0f1beb1db1a92025-08-20T03:08:36ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852024-12-0128134035210.1080/19768354.2024.2374547Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese miceSeul-Ki Mun0Chang Joo Jang1Semi Jo2Si-Hyoun Park3Hyun Bo Sim4Sonny C. Ramos5Hyeongyeong Kim6Yu-Jeong Choi7Dae-Han Park8Kyung-Wuk Park9Beom-Gyun Jeong10Dae Heon Kim11Kyung-Yun Kang12Jong-Jin Kim13Department of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaR&D team, Suncheon Research Center for Bio Health Care, Suncheon, Republic of KoreaR&D team, Suncheon Research Center for Bio Health Care, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaR&D team, Suncheon Research Center for Bio Health Care, Suncheon, Republic of KoreaDepartment of Biomedical Science, Sunchon National University, Suncheon, Republic of KoreaPreventing disease and maintaining the health of the elderly are crucial goals for an aging population, with obesity and immune function restoration being of paramount importance. Obesity, particularly visceral obesity characterized by excessive fat accumulation around the abdominal organs, is linked to chronic conditions such as diabetes, hypertension, cardiovascular diseases, and immune dysfunction. Globally, obesity is considered a disease, prompting significant research interest in its treatment. Therefore, it is essential to explore potential therapeutic and preventive strategies to address obesity and the decline in immune function brought about by aging. Tenebrio molitor larvae (TML), commonly known as ‘mealworms,’ are rich in unsaturated fatty acids, including oleic and linoleic acids, and essential amino acids, such as isoleucine and tyrosine. In this study, we aimed to investigate the effects of the consumption of TML oil and mealworm fermented extract (MWF-1) on obesity and immunological changes in aged obese mice. Our data showed reduced body fat in 23-week-old C57BL/6 mice fed processed TML products for 6 weeks. Additionally, the characteristically high levels of serum triglycerides decreased by treating with TML oil. The immune responsiveness results confirmed an increase in B cells by treating with MWF-1, while cytokine levels (interferon-gamma, tumor necrosis factor-alpha, interleukin-2, and −6) were restored to levels similar to young mice. These results suggest that TML oil and MWF-1 are promising dietary supplements for addressing obesity and restoring immune function.https://www.tandfonline.com/doi/10.1080/19768354.2024.2374547AgingobesityTenebrio molitorinsect consumptionimmunomodulatory effects |
| spellingShingle | Seul-Ki Mun Chang Joo Jang Semi Jo Si-Hyoun Park Hyun Bo Sim Sonny C. Ramos Hyeongyeong Kim Yu-Jeong Choi Dae-Han Park Kyung-Wuk Park Beom-Gyun Jeong Dae Heon Kim Kyung-Yun Kang Jong-Jin Kim Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice Animal Cells and Systems Aging obesity Tenebrio molitor insect consumption immunomodulatory effects |
| title | Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice |
| title_full | Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice |
| title_fullStr | Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice |
| title_full_unstemmed | Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice |
| title_short | Anti-obesity and immunomodulatory effects of oil and fermented extract dried from Tenebrio molitor larvae on aged obese mice |
| title_sort | anti obesity and immunomodulatory effects of oil and fermented extract dried from tenebrio molitor larvae on aged obese mice |
| topic | Aging obesity Tenebrio molitor insect consumption immunomodulatory effects |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2024.2374547 |
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