Brain-wide microstrokes affect the stability of memory circuits in the hippocampus
Abstract Cognitive deficits affect over 70% of stroke survivors, yet the mechanisms by which multiple small ischemic events contribute to cognitive decline remain poorly understood. In this study, we employed chronic two-photon calcium imaging to longitudinally track the fate of individual neurons i...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58688-4 |
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| author | Hendrik Heiser Filippo Kiessler Adrian Roggenbach Victor Ibanez Martin Wieckhorst Fritjof Helmchen Julijana Gjorgjieva Anna-Sophia Wahl |
| author_facet | Hendrik Heiser Filippo Kiessler Adrian Roggenbach Victor Ibanez Martin Wieckhorst Fritjof Helmchen Julijana Gjorgjieva Anna-Sophia Wahl |
| author_sort | Hendrik Heiser |
| collection | DOAJ |
| description | Abstract Cognitive deficits affect over 70% of stroke survivors, yet the mechanisms by which multiple small ischemic events contribute to cognitive decline remain poorly understood. In this study, we employed chronic two-photon calcium imaging to longitudinally track the fate of individual neurons in the hippocampus of mice navigating a virtual reality environment, both before and after inducing brain-wide microstrokes. Our findings reveal that, under normal conditions, hippocampal neurons exhibit varying degrees of stability in their spatial memory coding. However, microstrokes disrupted this functional network architecture, leading to cognitive impairments. Notably, the preservation of stable coding place cells, along with the stability, precision, and persistence of the hippocampal network, was strongly predictive of cognitive outcomes. Mice with more synchronously active place cells near important locations demonstrated recovery from cognitive impairment. This study uncovers critical cellular responses and network alterations following brain injury, providing a foundation for novel therapeutic strategies preventing cognitive decline. |
| format | Article |
| id | doaj-art-bcaa4b5c1b1c42a5a40bdd09aa5d5294 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-bcaa4b5c1b1c42a5a40bdd09aa5d52942025-08-20T02:28:04ZengNature PortfolioNature Communications2041-17232025-04-0116111710.1038/s41467-025-58688-4Brain-wide microstrokes affect the stability of memory circuits in the hippocampusHendrik Heiser0Filippo Kiessler1Adrian Roggenbach2Victor Ibanez3Martin Wieckhorst4Fritjof Helmchen5Julijana Gjorgjieva6Anna-Sophia Wahl7Brain Research Institute, University of ZurichSchool of Life Sciences, Technical University of MunichBrain Research Institute, University of ZurichBrain Research Institute, University of ZurichBrain Research Institute, University of ZurichBrain Research Institute, University of ZurichSchool of Life Sciences, Technical University of MunichBrain Research Institute, University of ZurichAbstract Cognitive deficits affect over 70% of stroke survivors, yet the mechanisms by which multiple small ischemic events contribute to cognitive decline remain poorly understood. In this study, we employed chronic two-photon calcium imaging to longitudinally track the fate of individual neurons in the hippocampus of mice navigating a virtual reality environment, both before and after inducing brain-wide microstrokes. Our findings reveal that, under normal conditions, hippocampal neurons exhibit varying degrees of stability in their spatial memory coding. However, microstrokes disrupted this functional network architecture, leading to cognitive impairments. Notably, the preservation of stable coding place cells, along with the stability, precision, and persistence of the hippocampal network, was strongly predictive of cognitive outcomes. Mice with more synchronously active place cells near important locations demonstrated recovery from cognitive impairment. This study uncovers critical cellular responses and network alterations following brain injury, providing a foundation for novel therapeutic strategies preventing cognitive decline.https://doi.org/10.1038/s41467-025-58688-4 |
| spellingShingle | Hendrik Heiser Filippo Kiessler Adrian Roggenbach Victor Ibanez Martin Wieckhorst Fritjof Helmchen Julijana Gjorgjieva Anna-Sophia Wahl Brain-wide microstrokes affect the stability of memory circuits in the hippocampus Nature Communications |
| title | Brain-wide microstrokes affect the stability of memory circuits in the hippocampus |
| title_full | Brain-wide microstrokes affect the stability of memory circuits in the hippocampus |
| title_fullStr | Brain-wide microstrokes affect the stability of memory circuits in the hippocampus |
| title_full_unstemmed | Brain-wide microstrokes affect the stability of memory circuits in the hippocampus |
| title_short | Brain-wide microstrokes affect the stability of memory circuits in the hippocampus |
| title_sort | brain wide microstrokes affect the stability of memory circuits in the hippocampus |
| url | https://doi.org/10.1038/s41467-025-58688-4 |
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