Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture
Introduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated the hypothesis of a bidirectional link betwee...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/684323 |
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| author | Alexander Fisher Wichat Srikusalanukul Michael Davis Paul Smith |
| author_facet | Alexander Fisher Wichat Srikusalanukul Michael Davis Paul Smith |
| author_sort | Alexander Fisher |
| collection | DOAJ |
| description | Introduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated the hypothesis of a bidirectional link between adipokines and osteocalcin. Materials and Methods. In a cross-sectional study of 294 older patients with osteoporotic hip fracture, we estimated serum concentrations of leptin, adiponectin, resistin, osteocalcin, parameters of mineral metabolism, and renal function. Results. After adjustment for multiple potential confounders, serum osteocalcin concentration was inversely associated with resistin and positively with leptin, leptin/resistin ratio, and adiponectin/resistin ratio. In multivariate regression models, osteocalcin was an independent predictor of serum leptin, resistin, leptin/resistin, and adiponectin/resistin ratios. Conclusions. Our data support the bidirectional regulation between osteocalcin and adipokines, but contrary to the genetically modified animal models, in older subjects with osteoporotic hip fracture, serum osteocalcin is positively associated with leptin and inversely with resistin. |
| format | Article |
| id | doaj-art-bca957353d444234a40260565f61bd0b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-bca957353d444234a40260565f61bd0b2025-02-03T05:48:13ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/684323684323Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip FractureAlexander Fisher0Wichat Srikusalanukul1Michael Davis2Paul Smith3Department of Geriatric Medicine, The Canberra Hospital, Canberra, P.O. Box 11, Woden, ACT 2606, AustraliaDepartment of Geriatric Medicine, The Canberra Hospital, Canberra, P.O. Box 11, Woden, ACT 2606, AustraliaDepartment of Geriatric Medicine, The Canberra Hospital, Canberra, P.O. Box 11, Woden, ACT 2606, AustraliaAustralian National University Medical School Canberra, Canberra, ACT 0200, AustraliaIntroduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated the hypothesis of a bidirectional link between adipokines and osteocalcin. Materials and Methods. In a cross-sectional study of 294 older patients with osteoporotic hip fracture, we estimated serum concentrations of leptin, adiponectin, resistin, osteocalcin, parameters of mineral metabolism, and renal function. Results. After adjustment for multiple potential confounders, serum osteocalcin concentration was inversely associated with resistin and positively with leptin, leptin/resistin ratio, and adiponectin/resistin ratio. In multivariate regression models, osteocalcin was an independent predictor of serum leptin, resistin, leptin/resistin, and adiponectin/resistin ratios. Conclusions. Our data support the bidirectional regulation between osteocalcin and adipokines, but contrary to the genetically modified animal models, in older subjects with osteoporotic hip fracture, serum osteocalcin is positively associated with leptin and inversely with resistin.http://dx.doi.org/10.1155/2012/684323 |
| spellingShingle | Alexander Fisher Wichat Srikusalanukul Michael Davis Paul Smith Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture International Journal of Endocrinology |
| title | Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture |
| title_full | Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture |
| title_fullStr | Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture |
| title_full_unstemmed | Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture |
| title_short | Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture |
| title_sort | interactions between serum adipokines and osteocalcin in older patients with hip fracture |
| url | http://dx.doi.org/10.1155/2012/684323 |
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