Association of Serum Bisphenol A with Hypertension in Thai Population
Objective. The present study aimed to examine the association between serum BPA and hypertension and evaluated whether it was influenced by estradiol level. Methods. A subsample of 2588 sera randomly selected from the Thai National Health Examination Survey IV, 2009, was measured for serum BPA and e...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2015/594189 |
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| author | Wichai Aekplakorn La-or Chailurkit Boonsong Ongphiphadhanakul |
| author_facet | Wichai Aekplakorn La-or Chailurkit Boonsong Ongphiphadhanakul |
| author_sort | Wichai Aekplakorn |
| collection | DOAJ |
| description | Objective. The present study aimed to examine the association between serum BPA and hypertension and evaluated whether it was influenced by estradiol level. Methods. A subsample of 2588 sera randomly selected from the Thai National Health Examination Survey IV, 2009, was measured for serum BPA and estradiol. Logistic regression was used to examine the association controlling for age, sex, diabetes, body mass index, and estradiol level. Results. Compared with the lowest quartile, the adjusted odds ratio (AOR) of hypertension for the fourth quartile of serum BPA was 2.16 (95% CI 1.31, 3.56) in women and 1.44 (0.99, 2.09) in men. There was no interaction between serum BPA and estradiol level. For analysis using log(BPA) as a continuous variable, the AOR per unit change in log(BPA) was 1.09 (95% CI 1.02, 1.16). Among postmenopausal women, the AOR for the fourth quartile of BPA was 2.33 (95% CI 1.31, 4.15) and, for premenopausal women, it was 2.12 (95% CI 0.87, 5.19). Conclusion. Serum BPA was independently associated with hypertension in women and was not likely to be affected by estrogen; however, its mechanism related to blood pressure needs further investigation. |
| format | Article |
| id | doaj-art-bca71c945f1b49d8b4a6554f6682ecc6 |
| institution | DOAJ |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-bca71c945f1b49d8b4a6554f6682ecc62025-08-20T03:23:19ZengWileyInternational Journal of Hypertension2090-03842090-03922015-01-01201510.1155/2015/594189594189Association of Serum Bisphenol A with Hypertension in Thai PopulationWichai Aekplakorn0La-or Chailurkit1Boonsong Ongphiphadhanakul2Department of Community Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandObjective. The present study aimed to examine the association between serum BPA and hypertension and evaluated whether it was influenced by estradiol level. Methods. A subsample of 2588 sera randomly selected from the Thai National Health Examination Survey IV, 2009, was measured for serum BPA and estradiol. Logistic regression was used to examine the association controlling for age, sex, diabetes, body mass index, and estradiol level. Results. Compared with the lowest quartile, the adjusted odds ratio (AOR) of hypertension for the fourth quartile of serum BPA was 2.16 (95% CI 1.31, 3.56) in women and 1.44 (0.99, 2.09) in men. There was no interaction between serum BPA and estradiol level. For analysis using log(BPA) as a continuous variable, the AOR per unit change in log(BPA) was 1.09 (95% CI 1.02, 1.16). Among postmenopausal women, the AOR for the fourth quartile of BPA was 2.33 (95% CI 1.31, 4.15) and, for premenopausal women, it was 2.12 (95% CI 0.87, 5.19). Conclusion. Serum BPA was independently associated with hypertension in women and was not likely to be affected by estrogen; however, its mechanism related to blood pressure needs further investigation.http://dx.doi.org/10.1155/2015/594189 |
| spellingShingle | Wichai Aekplakorn La-or Chailurkit Boonsong Ongphiphadhanakul Association of Serum Bisphenol A with Hypertension in Thai Population International Journal of Hypertension |
| title | Association of Serum Bisphenol A with Hypertension in Thai Population |
| title_full | Association of Serum Bisphenol A with Hypertension in Thai Population |
| title_fullStr | Association of Serum Bisphenol A with Hypertension in Thai Population |
| title_full_unstemmed | Association of Serum Bisphenol A with Hypertension in Thai Population |
| title_short | Association of Serum Bisphenol A with Hypertension in Thai Population |
| title_sort | association of serum bisphenol a with hypertension in thai population |
| url | http://dx.doi.org/10.1155/2015/594189 |
| work_keys_str_mv | AT wichaiaekplakorn associationofserumbisphenolawithhypertensioninthaipopulation AT laorchailurkit associationofserumbisphenolawithhypertensioninthaipopulation AT boonsongongphiphadhanakul associationofserumbisphenolawithhypertensioninthaipopulation |