Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke
<b>Background/Objectives</b>: Successful discourse relies not only on linguistic but also on prosodic information. Difficulty recognizing emotion conveyed through prosody (receptive affective aprosodia) following right hemisphere stroke (RHS) significantly disrupts communication particip...
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2025-07-01
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| author | Meyra S. Jackson Yuto Uchida Shannon M. Sheppard Kenichi Oishi Ciprian Crainiceanu Argye E. Hillis Alexandra Z. Durfee |
| author_facet | Meyra S. Jackson Yuto Uchida Shannon M. Sheppard Kenichi Oishi Ciprian Crainiceanu Argye E. Hillis Alexandra Z. Durfee |
| author_sort | Meyra S. Jackson |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Successful discourse relies not only on linguistic but also on prosodic information. Difficulty recognizing emotion conveyed through prosody (receptive affective aprosodia) following right hemisphere stroke (RHS) significantly disrupts communication participation and personal relationships. Growing evidence suggests that damage to white matter in addition to gray matter structures impairs affective prosody recognition. The current study investigates lesion–symptom associations in receptive affective aprosodia during RHS recovery by assessing whether disruptions in distinct white matter structures impact different underlying affective prosody recognition skills. <b>Methods</b>: Twenty-eight adults with RHS underwent neuroimaging and behavioral testing at acute, subacute, and chronic timepoints. Fifty-seven healthy matched controls completed the same behavioral testing, which comprised tasks targeting affective prosody recognition and underlying perceptual, cognitive, and linguistic skills. Linear mixed-effects models and multivariable linear regression were used to assess behavioral performance recovery and lesion–symptom associations. <b>Results</b>: Controls outperformed RHS participants on behavioral tasks earlier in recovery, and RHS participants’ affective prosody recognition significantly improved from acute to chronic testing. Affective prosody and emotional facial expression recognition were affected by external capsule and inferior fronto-occipital fasciculus lesions while sagittal stratum lesions impacted prosodic feature recognition. Accessing semantic representations of emotions implicated the superior longitudinal fasciculus. <b>Conclusions</b>: These findings replicate previously observed associations between right white matter tracts and affective prosody recognition and further identify lesion–symptom associations of underlying prosodic recognition skills throughout recovery. Investigation into prosody’s behavioral components and how they are affected by injury can help further intervention development and planning. |
| format | Article |
| id | doaj-art-bca504752cb346c094e157b241bb5b6d |
| institution | DOAJ |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-bca504752cb346c094e157b241bb5b6d2025-08-20T03:07:57ZengMDPI AGBrain Sciences2076-34252025-07-0115776910.3390/brainsci15070769Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere StrokeMeyra S. Jackson0Yuto Uchida1Shannon M. Sheppard2Kenichi Oishi3Ciprian Crainiceanu4Argye E. Hillis5Alexandra Z. Durfee6Department of Neurology, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USADepartment of Radiology, Johns Hopkins School of Medicine, 111 Market Place, Baltimore, MD 21202, USADepartment of Neurology, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USADepartment of Radiology, Johns Hopkins School of Medicine, 111 Market Place, Baltimore, MD 21202, USADepartment of Biostatistics, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USADepartment of Neurology, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USADepartment of Neurology, Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA<b>Background/Objectives</b>: Successful discourse relies not only on linguistic but also on prosodic information. Difficulty recognizing emotion conveyed through prosody (receptive affective aprosodia) following right hemisphere stroke (RHS) significantly disrupts communication participation and personal relationships. Growing evidence suggests that damage to white matter in addition to gray matter structures impairs affective prosody recognition. The current study investigates lesion–symptom associations in receptive affective aprosodia during RHS recovery by assessing whether disruptions in distinct white matter structures impact different underlying affective prosody recognition skills. <b>Methods</b>: Twenty-eight adults with RHS underwent neuroimaging and behavioral testing at acute, subacute, and chronic timepoints. Fifty-seven healthy matched controls completed the same behavioral testing, which comprised tasks targeting affective prosody recognition and underlying perceptual, cognitive, and linguistic skills. Linear mixed-effects models and multivariable linear regression were used to assess behavioral performance recovery and lesion–symptom associations. <b>Results</b>: Controls outperformed RHS participants on behavioral tasks earlier in recovery, and RHS participants’ affective prosody recognition significantly improved from acute to chronic testing. Affective prosody and emotional facial expression recognition were affected by external capsule and inferior fronto-occipital fasciculus lesions while sagittal stratum lesions impacted prosodic feature recognition. Accessing semantic representations of emotions implicated the superior longitudinal fasciculus. <b>Conclusions</b>: These findings replicate previously observed associations between right white matter tracts and affective prosody recognition and further identify lesion–symptom associations of underlying prosodic recognition skills throughout recovery. Investigation into prosody’s behavioral components and how they are affected by injury can help further intervention development and planning.https://www.mdpi.com/2076-3425/15/7/769emotionprosody recognitionreceptive aprosodiaright hemispherestroke recoverywhite matter |
| spellingShingle | Meyra S. Jackson Yuto Uchida Shannon M. Sheppard Kenichi Oishi Ciprian Crainiceanu Argye E. Hillis Alexandra Z. Durfee Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke Brain Sciences emotion prosody recognition receptive aprosodia right hemisphere stroke recovery white matter |
| title | Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke |
| title_full | Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke |
| title_fullStr | Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke |
| title_full_unstemmed | Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke |
| title_short | Elucidating White Matter Contributions to the Cognitive Architecture of Affective Prosody Recognition: Evidence from Right Hemisphere Stroke |
| title_sort | elucidating white matter contributions to the cognitive architecture of affective prosody recognition evidence from right hemisphere stroke |
| topic | emotion prosody recognition receptive aprosodia right hemisphere stroke recovery white matter |
| url | https://www.mdpi.com/2076-3425/15/7/769 |
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