When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?
Abstract N 6 -methyladenosine (m6A) is a prevalent and dynamic RNA modification, critical in regulating gene expression. Recent research has shed light on its significance in the life cycle of viruses, especially animal viruses. Depending on the context, these modifications can either enhance or inh...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s13567-024-01424-5 |
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| author | Wenjing Wang Yufei Jin Ziyun Xie Mei He Jing Li Zihan Wang Saiya Ma Wuchao Zhang Jie Tong |
| author_facet | Wenjing Wang Yufei Jin Ziyun Xie Mei He Jing Li Zihan Wang Saiya Ma Wuchao Zhang Jie Tong |
| author_sort | Wenjing Wang |
| collection | DOAJ |
| description | Abstract N 6 -methyladenosine (m6A) is a prevalent and dynamic RNA modification, critical in regulating gene expression. Recent research has shed light on its significance in the life cycle of viruses, especially animal viruses. Depending on the context, these modifications can either enhance or inhibit the replication of viruses. However, research on m6A modifications in animal virus genomes and the impact of viral infection on the host cell m6A landscape has been hindered due to the difficulty of detecting m6A sites at a single-nucleotide level. This article summarises the methods for detecting m6A in RNA. It then discusses the progress of research into m6A modification within animal viruses’ infections, such as influenza A virus, porcine epidemic diarrhoea virus, porcine reproductive, and respiratory syndrome virus. Finally, the review explores how m6A modification affects the following three aspects of the replication of animal RNA viruses: the regulation of viral genomic RNA function, the alteration of the m6A landscape in cells after viral infection, and the modulation of antiviral immunity through m6A modification. Research on m6A modifications in viral RNA sheds light on virus-host interactions at a molecular level. Understanding the impact of m6A on viral replication can help identify new targets for antiviral drug development and may uncover novel regulatory pathways that could potentially enhance antiviral immune responses. |
| format | Article |
| id | doaj-art-bca066dbf65545c9bc99aef63cf6e03f |
| institution | DOAJ |
| issn | 1297-9716 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj-art-bca066dbf65545c9bc99aef63cf6e03f2025-08-20T02:39:41ZengBMCVeterinary Research1297-97162024-12-0155111410.1186/s13567-024-01424-5When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse?Wenjing Wang0Yufei Jin1Ziyun Xie2Mei He3Jing Li4Zihan Wang5Saiya Ma6Wuchao Zhang7Jie Tong8College of Life Sciences, Hebei UniversityCollege of Life Sciences, Hebei UniversityCollege of Veterinary Medicine, Hebei Agriculture UniversityCollege of Life Sciences, Hebei UniversityCollege of Life Sciences, Hebei UniversityCollege of Life Sciences, Hebei UniversityCollege of Life Sciences, Hebei UniversityCollege of Veterinary Medicine, Hebei Agriculture UniversityCollege of Life Sciences, Hebei UniversityAbstract N 6 -methyladenosine (m6A) is a prevalent and dynamic RNA modification, critical in regulating gene expression. Recent research has shed light on its significance in the life cycle of viruses, especially animal viruses. Depending on the context, these modifications can either enhance or inhibit the replication of viruses. However, research on m6A modifications in animal virus genomes and the impact of viral infection on the host cell m6A landscape has been hindered due to the difficulty of detecting m6A sites at a single-nucleotide level. This article summarises the methods for detecting m6A in RNA. It then discusses the progress of research into m6A modification within animal viruses’ infections, such as influenza A virus, porcine epidemic diarrhoea virus, porcine reproductive, and respiratory syndrome virus. Finally, the review explores how m6A modification affects the following three aspects of the replication of animal RNA viruses: the regulation of viral genomic RNA function, the alteration of the m6A landscape in cells after viral infection, and the modulation of antiviral immunity through m6A modification. Research on m6A modifications in viral RNA sheds light on virus-host interactions at a molecular level. Understanding the impact of m6A on viral replication can help identify new targets for antiviral drug development and may uncover novel regulatory pathways that could potentially enhance antiviral immune responses.https://doi.org/10.1186/s13567-024-01424-5N 6 -methyladenosine (m6a)epigenetic modificationanimal virusvirus replicationantiviral immune responses |
| spellingShingle | Wenjing Wang Yufei Jin Ziyun Xie Mei He Jing Li Zihan Wang Saiya Ma Wuchao Zhang Jie Tong When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse? Veterinary Research N 6 -methyladenosine (m6a) epigenetic modification animal virus virus replication antiviral immune responses |
| title | When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse? |
| title_full | When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse? |
| title_fullStr | When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse? |
| title_full_unstemmed | When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse? |
| title_short | When animal viruses meet N6-methyladenosine (m6A) modifications: for better or worse? |
| title_sort | when animal viruses meet n6 methyladenosine m6a modifications for better or worse |
| topic | N 6 -methyladenosine (m6a) epigenetic modification animal virus virus replication antiviral immune responses |
| url | https://doi.org/10.1186/s13567-024-01424-5 |
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