Effect of testosterone treatment during puberty in boys with Klinefelter syndrome (The TIPY Study): protocol for a nationwide randomised, double-blinded, placebo-controlled study

Effect of testosterone treatment during puberty in boys with Klinefelter syndrome (The TIPY Study): protocol for a nationwide randomised, double-blinded, placebo-controlled study

Introduction Klinefelter syndrome (KS) is a genetic condition characterised by the presence of an extra X chromosome in males (47,XXY). KS is associated with various phenotypic characteristics in adult life, including infertility, hypogonadism and increased risk of type II diabetes, cardiovascular d...

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Main Authors: Gary Butler, Anders Juul, Judith L Ross, Jørgen Holm Petersen, Kurt Kristensen, Ann-Margrethe Rønholt Christensen, Ida Dyhr Caspersen, Andrés Felipe Østergaard Fritzbøger, Niels Birkebæk, Anders Jørgen Schou, Shanlee Davis, Sophie van Rijn, Lise Aksglaede
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/3/e095628.full
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