Local over-expression of VEGF-DΔNΔC in the uterine arteries of pregnant sheep results in long-term changes in uterine artery contractility and angiogenesis.

Local over-expression of VEGF-DΔNΔC in the uterine arteries of pregnant sheep results in long-term changes in uterine artery contractility and angiogenesis.

<h4>Background</h4>The normal development of the uteroplacental circulation in pregnancy depends on angiogenic and vasodilatory factors such as vascular endothelial growth factor (VEGF). Reduced uterine artery blood flow (UABF) is a common cause of fetal growth restriction; abnormalities...

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Bibliographic Details
Main Authors: Vedanta Mehta, Khalil N Abi-Nader, Panicos Shangaris, S W Steven Shaw, Elisa Filippi, Elizabeth Benjamin, Michael Boyd, Donald M Peebles, John Martin, Ian Zachary, Anna L David
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0100021
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