Chitosan powders and Ortho-R, a chitosan-containing finished product, are stable long term when stored in proper conditions
Chitosan has sometimes been perceived to have a poor stability, which may explain why only a few chitosan-based products are available commercially. The purpose of this study was to investigate the stability of two chitosan powders and of Ortho-R (ChitogenX Inc), a chitosan-containing finished produ...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893925001161 |
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| author | Anik Chevrier Dong Wang Elizabeth Ladd Jean-Simon Blais Marc Lavertu |
| author_facet | Anik Chevrier Dong Wang Elizabeth Ladd Jean-Simon Blais Marc Lavertu |
| author_sort | Anik Chevrier |
| collection | DOAJ |
| description | Chitosan has sometimes been perceived to have a poor stability, which may explain why only a few chitosan-based products are available commercially. The purpose of this study was to investigate the stability of two chitosan powders and of Ortho-R (ChitogenX Inc), a chitosan-containing finished product that is used as an adjunct to improve repair of soft tissues. The powders and Ortho-R product were subjected to accelerated (40 °C/75 % RH) and long-term (25 °C/60 % RH) stability testing. The chitosan number average molar mass (Mn), polydispersity index (PDI), degree of deacetylation (DDA) and water content did not change substantially throughout the stability testing period and remained within the established specifications. Forced degradation studies were also performed on the Ortho-R product by exposing it to light, heat, humidity, hydrochloric acid and hydrogen peroxide. Storing the Ortho-R product in an open vial under warm and humid conditions (40 °C/75 % RH) led to an increase in chitosan Mn and PDI. The Ortho-R product was sensitive to oxidation as revealed by a decrease in chitosan Mn and PDI. Chitosan powders and the Ortho-R finished product are stable in the long term when the proper container closure systems are used. |
| format | Article |
| id | doaj-art-bc96430acebb473ca9564e9e59986bd5 |
| institution | DOAJ |
| issn | 2666-8939 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-bc96430acebb473ca9564e9e59986bd52025-08-20T02:39:35ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392025-06-011010077710.1016/j.carpta.2025.100777Chitosan powders and Ortho-R, a chitosan-containing finished product, are stable long term when stored in proper conditionsAnik Chevrier0Dong Wang1Elizabeth Ladd2Jean-Simon Blais3Marc Lavertu4Chemical Engineering Department, Polytechnique Montreal, 2500 Chem. de Polytechnique, Montréal, QC, H3T 1J4, CanadaChemical Engineering Department, Polytechnique Montreal, 2500 Chem. de Polytechnique, Montréal, QC, H3T 1J4, CanadaKABS Laboratories Inc, 4500, rue de Tonnancour, St-Hubert, QC, J3Y 9G2, CanadaKABS Laboratories Inc, 4500, rue de Tonnancour, St-Hubert, QC, J3Y 9G2, CanadaChemical Engineering Department, Polytechnique Montreal, 2500 Chem. de Polytechnique, Montréal, QC, H3T 1J4, Canada; Biomedical Engineering Institute, Polytechnique Montreal, 2500 Chem. de Polytechnique, Montréal, QC, H3T 1J4, Canada; Corresponding author at: Department of Chemical Engineering, Polytechnique Montreal, PO Box 6079 Succ Centre-Ville, Montreal, Quebec, H3C 3A7, Canada.Chitosan has sometimes been perceived to have a poor stability, which may explain why only a few chitosan-based products are available commercially. The purpose of this study was to investigate the stability of two chitosan powders and of Ortho-R (ChitogenX Inc), a chitosan-containing finished product that is used as an adjunct to improve repair of soft tissues. The powders and Ortho-R product were subjected to accelerated (40 °C/75 % RH) and long-term (25 °C/60 % RH) stability testing. The chitosan number average molar mass (Mn), polydispersity index (PDI), degree of deacetylation (DDA) and water content did not change substantially throughout the stability testing period and remained within the established specifications. Forced degradation studies were also performed on the Ortho-R product by exposing it to light, heat, humidity, hydrochloric acid and hydrogen peroxide. Storing the Ortho-R product in an open vial under warm and humid conditions (40 °C/75 % RH) led to an increase in chitosan Mn and PDI. The Ortho-R product was sensitive to oxidation as revealed by a decrease in chitosan Mn and PDI. Chitosan powders and the Ortho-R finished product are stable in the long term when the proper container closure systems are used.http://www.sciencedirect.com/science/article/pii/S2666893925001161ChitosanAccelerated stabilityLong-term stabilityForced degradation |
| spellingShingle | Anik Chevrier Dong Wang Elizabeth Ladd Jean-Simon Blais Marc Lavertu Chitosan powders and Ortho-R, a chitosan-containing finished product, are stable long term when stored in proper conditions Carbohydrate Polymer Technologies and Applications Chitosan Accelerated stability Long-term stability Forced degradation |
| title | Chitosan powders and Ortho-R, a chitosan-containing finished product, are stable long term when stored in proper conditions |
| title_full | Chitosan powders and Ortho-R, a chitosan-containing finished product, are stable long term when stored in proper conditions |
| title_fullStr | Chitosan powders and Ortho-R, a chitosan-containing finished product, are stable long term when stored in proper conditions |
| title_full_unstemmed | Chitosan powders and Ortho-R, a chitosan-containing finished product, are stable long term when stored in proper conditions |
| title_short | Chitosan powders and Ortho-R, a chitosan-containing finished product, are stable long term when stored in proper conditions |
| title_sort | chitosan powders and ortho r a chitosan containing finished product are stable long term when stored in proper conditions |
| topic | Chitosan Accelerated stability Long-term stability Forced degradation |
| url | http://www.sciencedirect.com/science/article/pii/S2666893925001161 |
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