Review on role of honey in disease prevention and treatment through modulation of biological activities
Honey has been used for centuries due to its health-promoting properties. Honey and its bioactive compounds regulate oxidative stress, inflammation, and other biological activities, making it a promising natural remedy. Its role as anti-diabetic, wound healing, cardioprotective, anti-microbial, and...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2025-03-01
|
| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2025-1069 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850250640238837760 |
|---|---|
| author | Rahmani Arshad Husain Babiker Ali Yousif |
| author_facet | Rahmani Arshad Husain Babiker Ali Yousif |
| author_sort | Rahmani Arshad Husain |
| collection | DOAJ |
| description | Honey has been used for centuries due to its health-promoting properties. Honey and its bioactive compounds regulate oxidative stress, inflammation, and other biological activities, making it a promising natural remedy. Its role as anti-diabetic, wound healing, cardioprotective, anti-microbial, and hepatoprotective potential has been proven through in vitro and in vivo studies. Moreover, its role in disease management has been reported through the inhibition of pro-inflammatory enzymes and downregulation of pro-inflammatory cytokine expression and secretion. Besides, it exerts modulatory actions on various signaling pathways such as nuclear factor-κB, tumor suppressor genes, apoptosis, angiogenesis, and MAPK pathway. The main aim of this review is to present a wide-ranging overview of the current evidence regarding the impact of honey on the management of various pathogenic conditions. However, further research based on animal models and clinical trials is required to fully understand the mechanisms of action and safety in the management of various diseases. There is limited clinical data on honey and its mechanisms of action. However, comprehensive clinical studies are needed to fully investigate the potential health benefits of honey, including its efficacies, safety, bioavailability, and underlying mechanisms of action. |
| format | Article |
| id | doaj-art-bc93eebe09164535b521bcf2d1dca415 |
| institution | OA Journals |
| issn | 2391-5412 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj-art-bc93eebe09164535b521bcf2d1dca4152025-08-20T01:58:08ZengDe GruyterOpen Life Sciences2391-54122025-03-0120167845310.1515/biol-2025-1069Review on role of honey in disease prevention and treatment through modulation of biological activitiesRahmani Arshad Husain0Babiker Ali Yousif1Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah51452, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah51452, Saudi ArabiaHoney has been used for centuries due to its health-promoting properties. Honey and its bioactive compounds regulate oxidative stress, inflammation, and other biological activities, making it a promising natural remedy. Its role as anti-diabetic, wound healing, cardioprotective, anti-microbial, and hepatoprotective potential has been proven through in vitro and in vivo studies. Moreover, its role in disease management has been reported through the inhibition of pro-inflammatory enzymes and downregulation of pro-inflammatory cytokine expression and secretion. Besides, it exerts modulatory actions on various signaling pathways such as nuclear factor-κB, tumor suppressor genes, apoptosis, angiogenesis, and MAPK pathway. The main aim of this review is to present a wide-ranging overview of the current evidence regarding the impact of honey on the management of various pathogenic conditions. However, further research based on animal models and clinical trials is required to fully understand the mechanisms of action and safety in the management of various diseases. There is limited clinical data on honey and its mechanisms of action. However, comprehensive clinical studies are needed to fully investigate the potential health benefits of honey, including its efficacies, safety, bioavailability, and underlying mechanisms of action.https://doi.org/10.1515/biol-2025-1069honeyinflammationoxidative stressapoptosiswound healingcancerpathogenesis |
| spellingShingle | Rahmani Arshad Husain Babiker Ali Yousif Review on role of honey in disease prevention and treatment through modulation of biological activities Open Life Sciences honey inflammation oxidative stress apoptosis wound healing cancer pathogenesis |
| title | Review on role of honey in disease prevention and treatment through modulation of biological activities |
| title_full | Review on role of honey in disease prevention and treatment through modulation of biological activities |
| title_fullStr | Review on role of honey in disease prevention and treatment through modulation of biological activities |
| title_full_unstemmed | Review on role of honey in disease prevention and treatment through modulation of biological activities |
| title_short | Review on role of honey in disease prevention and treatment through modulation of biological activities |
| title_sort | review on role of honey in disease prevention and treatment through modulation of biological activities |
| topic | honey inflammation oxidative stress apoptosis wound healing cancer pathogenesis |
| url | https://doi.org/10.1515/biol-2025-1069 |
| work_keys_str_mv | AT rahmaniarshadhusain reviewonroleofhoneyindiseasepreventionandtreatmentthroughmodulationofbiologicalactivities AT babikeraliyousif reviewonroleofhoneyindiseasepreventionandtreatmentthroughmodulationofbiologicalactivities |