In silico profiling of neem limonoids and gut microbiome metabolites for Alzheimer’s therapeutics: targeted inhibition of BACE1 and elucidation of intricate molecular crosstalk with tau oligomers, and bacterial gingipains

In silico profiling of neem limonoids and gut microbiome metabolites for Alzheimer’s therapeutics: targeted inhibition of BACE1 and elucidation of intricate molecular crosstalk with tau oligomers, and bacterial gingipains

Abstract Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein. This study computationally investigated natural neem compounds (limonoids) and gut microbiome metabolites for their inhibitory poten...

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Bibliographic Details
Main Authors: Oluwaseun E. Agboola, Zainab A. Ayinla, Samuel S. Agboola, Esther Y. Omolayo, Abimbola E. Fadugba, Othuke B. Odeghe, Oluranti E. Olaiya, Babatunji E. Oyinloye
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Applied Sciences
Subjects:
Azadirachta indica
Alzheimer’s disease
Amyloid cascade
Gingipain proteases
Tau oligomerization
Gut microbiome metabolites
Online Access:https://doi.org/10.1007/s42452-025-06821-9
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