E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age
Purpose//objectives: A disproportionate incidence‘s increase of rectal cancer in patients younger than 50 years of age. The ESMO and NCCN recommendations are not age-specific and the literature is poor and conflicting. We decided to examine patients with rectal cancer treated in our centre in the la...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Clinical and Translational Radiation Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630824001824 |
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| author | E. Meldolesi A. Nicolì N. Dinapoli G. Chiloiro A. Romano R. Menghi R. Persiani F. Pacelli C. Coco C. Ratto S. Manfrida L. Boldrini B. Corvari M.A. Gambacorta |
| author_facet | E. Meldolesi A. Nicolì N. Dinapoli G. Chiloiro A. Romano R. Menghi R. Persiani F. Pacelli C. Coco C. Ratto S. Manfrida L. Boldrini B. Corvari M.A. Gambacorta |
| author_sort | E. Meldolesi |
| collection | DOAJ |
| description | Purpose//objectives: A disproportionate incidence‘s increase of rectal cancer in patients younger than 50 years of age. The ESMO and NCCN recommendations are not age-specific and the literature is poor and conflicting. We decided to examine patients with rectal cancer treated in our centre in the last 15 years with curative neoadjuvant radiochemotherapy comparing outcomes in the two groups under and over 55 years old. Materials/methods: 788 rectal cancer patients were enrolled in this monocentric retrospective observational study (523 =>55 years and 265 < 55). All patients received neoadjuvant chemoradiation treatment. R statistical software v.4.1.3 was used for the entire analysis. The outcomes were death, local recurrence, and new distant metastases. Survival analysis was performed using the Kaplan-Meier method and the Log-rank was used to compare the two groups. Results: All patients were classified in different risk groups, according to the ESMO 2017 rectal cancer clinical practice guidelines. 88 % of patients under 55 years old at the diagnosis belonged to the bad or advanced risk groups with an equal division. In patients over 55 years old, there was a clear dominance of the advanced risk class (62 % of the total). In multivariate analysis, OS and DFS decrease with increasing age and ESMO risk group. The other variables in multivariate were not significant. For Both OS, DFS and MFS, the curves separated significantly at 55 years of age, with a prevalence of metastasis development in the older group. Conclusion: Elderly patients have a prevalence of advanced disease. Younger patients seem having a better OS at 3 and 5 years. ESMO risk group and age were the only variables affecting OS and DFS. Young patients have better MFS and DFS at 2 and 5 years than patients older than 55 years. The addition of oxaliplatin to fluoropyrimidine-based neoadjuvant chemotherapy resulted not significant in both groups. |
| format | Article |
| id | doaj-art-bc92153715024a45bb9519ff5228bbb6 |
| institution | Kabale University |
| issn | 2405-6308 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj-art-bc92153715024a45bb9519ff5228bbb62025-01-30T05:14:27ZengElsevierClinical and Translational Radiation Oncology2405-63082025-03-0151100905E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young ageE. Meldolesi0A. Nicolì1N. Dinapoli2G. Chiloiro3A. Romano4R. Menghi5R. Persiani6F. Pacelli7C. Coco8C. Ratto9S. Manfrida10L. Boldrini11B. Corvari12M.A. Gambacorta13Department of Diagnostic Imaging, Radiation Oncology and Haematology, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Rome, ItalyDepartment of Palliative Care, ASL Lecce, San Cesario di Lecce, Lecce, Italy; Corresponding author.Department of Diagnostic Imaging, Radiation Oncology and Haematology, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Rome, ItalyDepartment of Diagnostic Imaging, Radiation Oncology and Haematology, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Rome, ItalyDepartment of Diagnostic Imaging, Radiation Oncology and Haematology, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Rome, ItalyDigestive Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyDigestive Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyDigestive Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyDigestive Surgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, ItalyProctology and Pelvic Floor Surgery Unit, Center of Excellence for Gastrointestinal and Endocrine-Metabolic Diseases, Isola Tiberina - Gemelli Isola Hospital, Rome, ItalyDepartment of Diagnostic Imaging, Radiation Oncology and Haematology, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Rome, ItalyDepartment of Diagnostic Imaging, Radiation Oncology and Haematology, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Rome, ItalyDepartment of Diagnostic Imaging, Radiation Oncology and Haematology, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Rome, ItalyDepartment of Diagnostic Imaging, Radiation Oncology and Haematology, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Rome, ItalyPurpose//objectives: A disproportionate incidence‘s increase of rectal cancer in patients younger than 50 years of age. The ESMO and NCCN recommendations are not age-specific and the literature is poor and conflicting. We decided to examine patients with rectal cancer treated in our centre in the last 15 years with curative neoadjuvant radiochemotherapy comparing outcomes in the two groups under and over 55 years old. Materials/methods: 788 rectal cancer patients were enrolled in this monocentric retrospective observational study (523 =>55 years and 265 < 55). All patients received neoadjuvant chemoradiation treatment. R statistical software v.4.1.3 was used for the entire analysis. The outcomes were death, local recurrence, and new distant metastases. Survival analysis was performed using the Kaplan-Meier method and the Log-rank was used to compare the two groups. Results: All patients were classified in different risk groups, according to the ESMO 2017 rectal cancer clinical practice guidelines. 88 % of patients under 55 years old at the diagnosis belonged to the bad or advanced risk groups with an equal division. In patients over 55 years old, there was a clear dominance of the advanced risk class (62 % of the total). In multivariate analysis, OS and DFS decrease with increasing age and ESMO risk group. The other variables in multivariate were not significant. For Both OS, DFS and MFS, the curves separated significantly at 55 years of age, with a prevalence of metastasis development in the older group. Conclusion: Elderly patients have a prevalence of advanced disease. Younger patients seem having a better OS at 3 and 5 years. ESMO risk group and age were the only variables affecting OS and DFS. Young patients have better MFS and DFS at 2 and 5 years than patients older than 55 years. The addition of oxaliplatin to fluoropyrimidine-based neoadjuvant chemotherapy resulted not significant in both groups.http://www.sciencedirect.com/science/article/pii/S2405630824001824Young rectal cancerRadiochemotherapyJuvenile rectal cancer |
| spellingShingle | E. Meldolesi A. Nicolì N. Dinapoli G. Chiloiro A. Romano R. Menghi R. Persiani F. Pacelli C. Coco C. Ratto S. Manfrida L. Boldrini B. Corvari M.A. Gambacorta E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age Clinical and Translational Radiation Oncology Young rectal cancer Radiochemotherapy Juvenile rectal cancer |
| title | E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age |
| title_full | E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age |
| title_fullStr | E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age |
| title_full_unstemmed | E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age |
| title_short | E_N_T_R_O_P_Y: Monocentric analysis of rectal cancer radio-chemotherapy treatment in patients of young age |
| title_sort | e n t r o p y monocentric analysis of rectal cancer radio chemotherapy treatment in patients of young age |
| topic | Young rectal cancer Radiochemotherapy Juvenile rectal cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2405630824001824 |
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