Impairment of gut defense barrier and microbial translocation in HIV-infection
Translocation of bacterial components, including endotoxin of gram-negative microorganisms, is considered as one of the factors, contributing to hyperactivation of immune system in HIV-infection and progression of the disease. Possible reasons for increased intestinal permeability are discussed: mas...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/111 |
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| _version_ | 1849687690248716288 |
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| author | G. R. Khasanova |
| author_facet | G. R. Khasanova |
| author_sort | G. R. Khasanova |
| collection | DOAJ |
| description | Translocation of bacterial components, including endotoxin of gram-negative microorganisms, is considered as one of the factors, contributing to hyperactivation of immune system in HIV-infection and progression of the disease. Possible reasons for increased intestinal permeability are discussed: massive loss of intestinal CD4-lymphocytes, especially during acute phase of disease, significant decrease in tight junction protein expression, on-going viral replication and constant inflammation of gut mucosa, altered gut micro ecology. Results of investigations of the role of microbial translocation in progression of HIV-infection are presented. |
| format | Article |
| id | doaj-art-bc86dcebacc64a26a23aa73db0f61666 |
| institution | DOAJ |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-bc86dcebacc64a26a23aa73db0f616662025-08-20T03:22:15ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0143354110.22625/2072-6732-2012-4-3-35-41125Impairment of gut defense barrier and microbial translocation in HIV-infectionG. R. Khasanova0Kazan State Medical University, KazanTranslocation of bacterial components, including endotoxin of gram-negative microorganisms, is considered as one of the factors, contributing to hyperactivation of immune system in HIV-infection and progression of the disease. Possible reasons for increased intestinal permeability are discussed: massive loss of intestinal CD4-lymphocytes, especially during acute phase of disease, significant decrease in tight junction protein expression, on-going viral replication and constant inflammation of gut mucosa, altered gut micro ecology. Results of investigations of the role of microbial translocation in progression of HIV-infection are presented.https://journal.niidi.ru/jofin/article/view/111hiv-infectionmicrobial translocationactivation of immune systemendotoxin |
| spellingShingle | G. R. Khasanova Impairment of gut defense barrier and microbial translocation in HIV-infection Журнал инфектологии hiv-infection microbial translocation activation of immune system endotoxin |
| title | Impairment of gut defense barrier and microbial translocation in HIV-infection |
| title_full | Impairment of gut defense barrier and microbial translocation in HIV-infection |
| title_fullStr | Impairment of gut defense barrier and microbial translocation in HIV-infection |
| title_full_unstemmed | Impairment of gut defense barrier and microbial translocation in HIV-infection |
| title_short | Impairment of gut defense barrier and microbial translocation in HIV-infection |
| title_sort | impairment of gut defense barrier and microbial translocation in hiv infection |
| topic | hiv-infection microbial translocation activation of immune system endotoxin |
| url | https://journal.niidi.ru/jofin/article/view/111 |
| work_keys_str_mv | AT grkhasanova impairmentofgutdefensebarrierandmicrobialtranslocationinhivinfection |