Integrated renin angiotensin system dysregulation and immune profiles predict COVID-19 disease severity in a South African cohort

Integrated renin angiotensin system dysregulation and immune profiles predict COVID-19 disease severity in a South African cohort

Abstract Renin-angiotensin system (RAS) dysregulation is an important component of the complex pathophysiology of SARS-CoV-2 and other coronavirus infections. Thus, angiotensin-converting enzyme 2 (ACE2), the entry receptor and key to the alternative RAS, was proposed as a severity/prognostic biomar...

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Bibliographic Details
Main Authors: Talitha Müller, Sonwabile Dzanibe, Cascia Day, Phelelani Thokozani Mpangase, Tafadzwa Chimbetete, Sarah Pedretti, Sylva Schwager, Clive M. Gray, Edward Sturrock, Jonny Peter
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
ACE2
RAS
COVID-19
MDSC
Biomarkers
SARS-CoV-2
Online Access:https://doi.org/10.1038/s41598-025-96161-w
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