ARHGAP4/MYH9/β-catenin/c-Jun positive feedback loop promotes colorectal cancer stemness

ARHGAP4/MYH9/β-catenin/c-Jun positive feedback loop promotes colorectal cancer stemness

Abstract Rho GTPase-activating protein 4 (ARHGAP4) is implicated in poor prognosis across multiple malignancies. However, its role in driving stemness in colorectal cancer (CRC) remains unclear. In this study, we demonstrate that ARHGAP4 drives CRC stemness through a positive feedback loop involving...

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Bibliographic Details
Main Authors: Shaolin Liu, Yizhen Chen, Song Tan, Yifan Chen, Changshun Yang, Yulong Mi, Shengtao Lin, Weihua Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01022-4
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