Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2011/587495 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849684930257223680 |
|---|---|
| author | Sandeep Kumar Mathur Priyanka Jain Prashant Mathur |
| author_facet | Sandeep Kumar Mathur Priyanka Jain Prashant Mathur |
| author_sort | Sandeep Kumar Mathur |
| collection | DOAJ |
| description | Clustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy. Microarray is a powerful technique of assessment of gene function by measuring transcription of large number of genes in an array. This technique has several potential applications in understanding pathologic adipose tissue. They are: (1) transcriptomic differences between various depots of adipose tissue, adipose tissue from obese versus lean individuals, high insulin resistant versus low insulin resistance, brown versus white adipose tissue, (2) transcriptomic profiles of various stages of adipogenesis, (3) effect of diet, cytokines, adipokines, hormones, environmental toxins and drugs on transcriptomic profiles, (4) influence of adipokines on transcriptomic profiles in skeletal muscle, hepatocyte, adipose tissue etc., and (5) genetics of gene expression. The microarray evidences of molecular basis of obesity and insulin resistance are presented here. Despite the limitations, microarray has potential clinical applications in finding new molecular targets for treatment of insulin resistance and classification of adipose tissue based on future risk of insulin resistance syndrome. |
| format | Article |
| id | doaj-art-bc74e2529066400b97604f4fbfde3740 |
| institution | DOAJ |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-bc74e2529066400b97604f4fbfde37402025-08-20T03:23:19ZengWileyJournal of Obesity2090-07082090-07162011-01-01201110.1155/2011/587495587495Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical ImplicationsSandeep Kumar Mathur0Priyanka Jain1Prashant Mathur2Department of Endocrinology, S. M. S. Medical College, IndiaInstitute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, IndiaDepartment of Pharmacology, S. M. S. Medical College, J. L. Marg, Jaipur 302004, IndiaClustering of insulin resistance and dysmetabolism with obesity is attributed to pathologic adipose tissue. The morphologic hallmarks of this pathology are adipocye hypertrophy and heightened inflammation. However, it's underlying molecular mechanisms remains unknown. Study of gene function in metabolically active tissues like adipose tissue, skeletal muscle and liver is a promising strategy. Microarray is a powerful technique of assessment of gene function by measuring transcription of large number of genes in an array. This technique has several potential applications in understanding pathologic adipose tissue. They are: (1) transcriptomic differences between various depots of adipose tissue, adipose tissue from obese versus lean individuals, high insulin resistant versus low insulin resistance, brown versus white adipose tissue, (2) transcriptomic profiles of various stages of adipogenesis, (3) effect of diet, cytokines, adipokines, hormones, environmental toxins and drugs on transcriptomic profiles, (4) influence of adipokines on transcriptomic profiles in skeletal muscle, hepatocyte, adipose tissue etc., and (5) genetics of gene expression. The microarray evidences of molecular basis of obesity and insulin resistance are presented here. Despite the limitations, microarray has potential clinical applications in finding new molecular targets for treatment of insulin resistance and classification of adipose tissue based on future risk of insulin resistance syndrome.http://dx.doi.org/10.1155/2011/587495 |
| spellingShingle | Sandeep Kumar Mathur Priyanka Jain Prashant Mathur Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications Journal of Obesity |
| title | Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications |
| title_full | Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications |
| title_fullStr | Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications |
| title_full_unstemmed | Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications |
| title_short | Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications |
| title_sort | microarray evidences the role of pathologic adipose tissue in insulin resistance and their clinical implications |
| url | http://dx.doi.org/10.1155/2011/587495 |
| work_keys_str_mv | AT sandeepkumarmathur microarrayevidencestheroleofpathologicadiposetissueininsulinresistanceandtheirclinicalimplications AT priyankajain microarrayevidencestheroleofpathologicadiposetissueininsulinresistanceandtheirclinicalimplications AT prashantmathur microarrayevidencestheroleofpathologicadiposetissueininsulinresistanceandtheirclinicalimplications |