The combination of fatigue with the serum GCSF improves the performance of serological screening for frailty
Frailty is a critical cause leading to elderly death. No drug is available to treat it, while prevention works. However, reliable blood screening and diagnostic methods for frailty are still lacking. Here, we show that the serum GCSF, in co...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2025-02-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2025007 |
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| author | Yu Jiaming Chen Jie Ji Xueying Qiu Yixuan Zhang Yan Wang Jiaofeng Li Xiangqi Zhang Chaobao Bao Zhijun |
| author_facet | Yu Jiaming Chen Jie Ji Xueying Qiu Yixuan Zhang Yan Wang Jiaofeng Li Xiangqi Zhang Chaobao Bao Zhijun |
| author_sort | Yu Jiaming |
| collection | DOAJ |
| description | Frailty is a critical cause leading to elderly death. No drug is available to treat it, while prevention works. However, reliable blood screening and diagnostic methods for frailty are still lacking. Here, we show that the serum GCSF, in combination with the fatigue factor of the frailty scale, can improve the performance of serological screening for frailty. • Proteomics studies indicate that frailty and aging exhibit distinct inflammatory niches. • Among 15 serum inflammatory markers, IFNγ, GCSF, and TNFα are significantly reduced in frail patients. • The combination of serum GCSF level and fatigue factor among the frailty scale can be used for frailty screening. |
| format | Article |
| id | doaj-art-bc7376b8b68440c1a5b16bb202dc64cc |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-bc7376b8b68440c1a5b16bb202dc64cc2025-08-20T03:41:00ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452025-02-01571195119810.3724/abbs.202500720d259ccThe combination of fatigue with the serum GCSF improves the performance of serological screening for frailtyYu Jiaming0Chen Jie1Ji Xueying2Qiu Yixuan3Zhang Yan4Wang Jiaofeng5Li Xiangqi6Zhang Chaobao7Bao Zhijun8["Shanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China","National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China"]["Shanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"]["Shanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"]["Shanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"]["Shanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"]["Shanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China"]["Department of Endocrinology and Metabolism, Gongli Hospital, Shanghai 200135, China"]["Shanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China","National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China"]["Shanghai Key Laboratory of Clinical Geriatric Medicine; Department of Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China","National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China"]Frailty is a critical cause leading to elderly death. No drug is available to treat it, while prevention works. However, reliable blood screening and diagnostic methods for frailty are still lacking. Here, we show that the serum GCSF, in combination with the fatigue factor of the frailty scale, can improve the performance of serological screening for frailty. • Proteomics studies indicate that frailty and aging exhibit distinct inflammatory niches. • Among 15 serum inflammatory markers, IFNγ, GCSF, and TNFα are significantly reduced in frail patients. • The combination of serum GCSF level and fatigue factor among the frailty scale can be used for frailty screening.https://www.sciengine.com/doi/10.3724/abbs.2025007 |
| spellingShingle | Yu Jiaming Chen Jie Ji Xueying Qiu Yixuan Zhang Yan Wang Jiaofeng Li Xiangqi Zhang Chaobao Bao Zhijun The combination of fatigue with the serum GCSF improves the performance of serological screening for frailty Acta Biochimica et Biophysica Sinica |
| title | The combination of fatigue with the serum GCSF improves the performance of serological screening for frailty |
| title_full | The combination of fatigue with the serum GCSF improves the performance of serological screening for frailty |
| title_fullStr | The combination of fatigue with the serum GCSF improves the performance of serological screening for frailty |
| title_full_unstemmed | The combination of fatigue with the serum GCSF improves the performance of serological screening for frailty |
| title_short | The combination of fatigue with the serum GCSF improves the performance of serological screening for frailty |
| title_sort | combination of fatigue with the serum gcsf improves the performance of serological screening for frailty |
| url | https://www.sciengine.com/doi/10.3724/abbs.2025007 |
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