Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British Columbia

Two major outbreaks of invasive meningococcal disease serogroup C (IMD-C) were identified in British Columbia between 2000 and 2004. Pulsed-field gel electrophoresis (PFGE) and porA gene sequencing of all retained IMD-C isolates were used to assess correlations between genotypes and epidemiological...

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Main Authors: Grahame Quan, Mark Gilbert, Samara T David, Tazim Rahim, Kathy Adie, Carol Shaw, Alan McNabb, Judy Isaac-Renton, David M Patrick
Format: Article
Language:English
Published: Wiley 2007-01-01
Series:Canadian Journal of Infectious Diseases and Medical Microbiology
Online Access:http://dx.doi.org/10.1155/2007/295973
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author Grahame Quan
Mark Gilbert
Samara T David
Tazim Rahim
Kathy Adie
Carol Shaw
Alan McNabb
Judy Isaac-Renton
David M Patrick
author_facet Grahame Quan
Mark Gilbert
Samara T David
Tazim Rahim
Kathy Adie
Carol Shaw
Alan McNabb
Judy Isaac-Renton
David M Patrick
author_sort Grahame Quan
collection DOAJ
description Two major outbreaks of invasive meningococcal disease serogroup C (IMD-C) were identified in British Columbia between 2000 and 2004. Pulsed-field gel electrophoresis (PFGE) and porA gene sequencing of all retained IMD-C isolates were used to assess correlations between genotypes and epidemiological patterns. PFGE patterns of IMD-C genotypes correlated with epidemiological patterns between 2000 and 2004 in British Columbia, and demonstrated that PFGE can identify outbreak-related cases. Both IMD-C outbreaks correlated with a respective PFGE pattern. PFGE analysis demonstrated that the 2004 British Columbia outbreak strain in men who have sex with men was closely related to the 2001 Abbotsford outbreak strain. PorA sequencing data indicated low diversity of class 1 outer membrane proteins in British Columbia, and did not correlate with epidemiological trends. There was a trend for outbreak-associated PFGE types to demonstrate higher case fatality rates.
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institution Kabale University
issn 1712-9532
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publishDate 2007-01-01
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series Canadian Journal of Infectious Diseases and Medical Microbiology
spelling doaj-art-bc72b46e69ba4c2eb6cffb2dc0c2ddbd2025-02-03T05:45:40ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322007-01-0118636336710.1155/2007/295973Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British ColumbiaGrahame Quan0Mark Gilbert1Samara T David2Tazim Rahim3Kathy Adie4Carol Shaw5Alan McNabb6Judy Isaac-Renton7David M Patrick8University of British Columbia, Vancouver, British Columbia, CanadaUniversity of British Columbia, Vancouver, British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaUniversity of British Columbia, Vancouver, British Columbia, CanadaUniversity of British Columbia, Vancouver, British Columbia, CanadaTwo major outbreaks of invasive meningococcal disease serogroup C (IMD-C) were identified in British Columbia between 2000 and 2004. Pulsed-field gel electrophoresis (PFGE) and porA gene sequencing of all retained IMD-C isolates were used to assess correlations between genotypes and epidemiological patterns. PFGE patterns of IMD-C genotypes correlated with epidemiological patterns between 2000 and 2004 in British Columbia, and demonstrated that PFGE can identify outbreak-related cases. Both IMD-C outbreaks correlated with a respective PFGE pattern. PFGE analysis demonstrated that the 2004 British Columbia outbreak strain in men who have sex with men was closely related to the 2001 Abbotsford outbreak strain. PorA sequencing data indicated low diversity of class 1 outer membrane proteins in British Columbia, and did not correlate with epidemiological trends. There was a trend for outbreak-associated PFGE types to demonstrate higher case fatality rates.http://dx.doi.org/10.1155/2007/295973
spellingShingle Grahame Quan
Mark Gilbert
Samara T David
Tazim Rahim
Kathy Adie
Carol Shaw
Alan McNabb
Judy Isaac-Renton
David M Patrick
Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British Columbia
Canadian Journal of Infectious Diseases and Medical Microbiology
title Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British Columbia
title_full Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British Columbia
title_fullStr Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British Columbia
title_full_unstemmed Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British Columbia
title_short Usefulness of Pulsed-Field Gel Electrophoresis in Tracking Two Outbreaks of Invasive Meningococcal Disease Serogroup C in British Columbia
title_sort usefulness of pulsed field gel electrophoresis in tracking two outbreaks of invasive meningococcal disease serogroup c in british columbia
url http://dx.doi.org/10.1155/2007/295973
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