Erythema nodosum manifestation of Parvovirus B19-associated reactive arthritis
Introduction: Parvovirus B19 virus-mediated viral inflammation and immune-complex deposition generate mainly short-term manifestations in the affected individuals. The objective of this study was to determine Parvovirus B19 infection in rheumatoid arthritis (RA) patients. Methodology: The study e...
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The Journal of Infection in Developing Countries
2024-09-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/19513 |
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| author | Maryam Kareem Ali Jaafar Sataar Shia |
| author_facet | Maryam Kareem Ali Jaafar Sataar Shia |
| author_sort | Maryam Kareem Ali |
| collection | DOAJ |
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Introduction: Parvovirus B19 virus-mediated viral inflammation and immune-complex deposition generate mainly short-term manifestations in the affected individuals. The objective of this study was to determine Parvovirus B19 infection in rheumatoid arthritis (RA) patients.
Methodology: The study employed 50 patients diagnosed with RA and 30 healthy individuals. Blood samples were collected from both groups. The blood samples were screened for Parvovirus B19 infection using polymerase chain reaction to detect B19 DNA and enzyme-linked immunosorbent assay to detect anti-B19 IgM and IgG.
Results: 17 (34%) of 50 patients tested positive for parvovirus B19 DNA. In contrast, the mortality rate in the control group was significantly lower (6.7%; p = 0.005). Anti-B19 IgG antibody levels differed significantly with patients and control (p = 0.007), whereas anti-B19 IgM Ab levels did not (p = 0.6). There was a significant correlation between viremia B19 and all measured parameters. Parvovirus-affected patients had significantly higher CRP and ESR, elevated DAS28 scores, and more joint pain compared to parvovirus (-) patients.
Conclusion: Anti-CCP and RF values were significantly high in parvovirus (+) patients. Joint erosion was also prevalent in patients who tested positive for parvovirus. The findings of this study suggest that infection with parvovirus in patients with RA, and a possible role of this viral infection in the pathogenesis of RA may contribute to the pathogenesis of RA.
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| format | Article |
| id | doaj-art-bc6a5222a2cb4b35bd5063c42a147b8f |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-bc6a5222a2cb4b35bd5063c42a147b8f2025-08-20T03:52:39ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-09-01180910.3855/jidc.19513Erythema nodosum manifestation of Parvovirus B19-associated reactive arthritisMaryam Kareem Ali0Jaafar Sataar Shia1Department of Microbiology, College of Medicine, University of Baghdad, IraqDepartment of Pharmacy, Al-Farabi University College, Baghdad, Iraq Introduction: Parvovirus B19 virus-mediated viral inflammation and immune-complex deposition generate mainly short-term manifestations in the affected individuals. The objective of this study was to determine Parvovirus B19 infection in rheumatoid arthritis (RA) patients. Methodology: The study employed 50 patients diagnosed with RA and 30 healthy individuals. Blood samples were collected from both groups. The blood samples were screened for Parvovirus B19 infection using polymerase chain reaction to detect B19 DNA and enzyme-linked immunosorbent assay to detect anti-B19 IgM and IgG. Results: 17 (34%) of 50 patients tested positive for parvovirus B19 DNA. In contrast, the mortality rate in the control group was significantly lower (6.7%; p = 0.005). Anti-B19 IgG antibody levels differed significantly with patients and control (p = 0.007), whereas anti-B19 IgM Ab levels did not (p = 0.6). There was a significant correlation between viremia B19 and all measured parameters. Parvovirus-affected patients had significantly higher CRP and ESR, elevated DAS28 scores, and more joint pain compared to parvovirus (-) patients. Conclusion: Anti-CCP and RF values were significantly high in parvovirus (+) patients. Joint erosion was also prevalent in patients who tested positive for parvovirus. The findings of this study suggest that infection with parvovirus in patients with RA, and a possible role of this viral infection in the pathogenesis of RA may contribute to the pathogenesis of RA. https://jidc.org/index.php/journal/article/view/19513ParvovirusErythema nodosumrheumatoid arthritis |
| spellingShingle | Maryam Kareem Ali Jaafar Sataar Shia Erythema nodosum manifestation of Parvovirus B19-associated reactive arthritis Journal of Infection in Developing Countries Parvovirus Erythema nodosum rheumatoid arthritis |
| title | Erythema nodosum manifestation of Parvovirus B19-associated reactive arthritis |
| title_full | Erythema nodosum manifestation of Parvovirus B19-associated reactive arthritis |
| title_fullStr | Erythema nodosum manifestation of Parvovirus B19-associated reactive arthritis |
| title_full_unstemmed | Erythema nodosum manifestation of Parvovirus B19-associated reactive arthritis |
| title_short | Erythema nodosum manifestation of Parvovirus B19-associated reactive arthritis |
| title_sort | erythema nodosum manifestation of parvovirus b19 associated reactive arthritis |
| topic | Parvovirus Erythema nodosum rheumatoid arthritis |
| url | https://jidc.org/index.php/journal/article/view/19513 |
| work_keys_str_mv | AT maryamkareemali erythemanodosummanifestationofparvovirusb19associatedreactivearthritis AT jaafarsataarshia erythemanodosummanifestationofparvovirusb19associatedreactivearthritis |