Switchable electrochemical pathways for the selective C(sp3)-Ge bond formation
Abstract The development of efficient and general strategies for constructing alkyl germanes is crucial due to their significant roles in various areas that impact human quality of life. Herein, we report a robust electrochemically driven method for the construction of alkyl germanes, utilizing a va...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-62141-x |
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| _version_ | 1849332064053100544 |
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| author | Haifeng Chen Cai Zhai Huabing Zhang Chen Zhu Magnus Rueping |
| author_facet | Haifeng Chen Cai Zhai Huabing Zhang Chen Zhu Magnus Rueping |
| author_sort | Haifeng Chen |
| collection | DOAJ |
| description | Abstract The development of efficient and general strategies for constructing alkyl germanes is crucial due to their significant roles in various areas that impact human quality of life. Herein, we report a robust electrochemically driven method for the construction of alkyl germanes, utilizing a variety of functionalized alkyl nitriles and commercially available chlorogermanes. The developed decyanative germylation approach allows for the efficient and modular preparation of a wide range of structurally diverse alkyl germanes under mild reaction conditions. Notably, primary, secondary, and tertiary alkyl nitriles are all compatible. Furthermore, a series of natural product and drug-derived substrates undergo smooth late-stage functionalization, yielding the corresponding complex alkyl germanes. |
| format | Article |
| id | doaj-art-bc6a450c20a045ecb181117dd122b683 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-bc6a450c20a045ecb181117dd122b6832025-08-20T03:46:20ZengNature PortfolioNature Communications2041-17232025-08-0116111210.1038/s41467-025-62141-xSwitchable electrochemical pathways for the selective C(sp3)-Ge bond formationHaifeng Chen0Cai Zhai1Huabing Zhang2Chen Zhu3Magnus Rueping4KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST)Ningbo Institute of Digital Twin, Eastern Institute of TechnologyKAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST)Ningbo Institute of Digital Twin, Eastern Institute of TechnologyKAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST)Abstract The development of efficient and general strategies for constructing alkyl germanes is crucial due to their significant roles in various areas that impact human quality of life. Herein, we report a robust electrochemically driven method for the construction of alkyl germanes, utilizing a variety of functionalized alkyl nitriles and commercially available chlorogermanes. The developed decyanative germylation approach allows for the efficient and modular preparation of a wide range of structurally diverse alkyl germanes under mild reaction conditions. Notably, primary, secondary, and tertiary alkyl nitriles are all compatible. Furthermore, a series of natural product and drug-derived substrates undergo smooth late-stage functionalization, yielding the corresponding complex alkyl germanes.https://doi.org/10.1038/s41467-025-62141-x |
| spellingShingle | Haifeng Chen Cai Zhai Huabing Zhang Chen Zhu Magnus Rueping Switchable electrochemical pathways for the selective C(sp3)-Ge bond formation Nature Communications |
| title | Switchable electrochemical pathways for the selective C(sp3)-Ge bond formation |
| title_full | Switchable electrochemical pathways for the selective C(sp3)-Ge bond formation |
| title_fullStr | Switchable electrochemical pathways for the selective C(sp3)-Ge bond formation |
| title_full_unstemmed | Switchable electrochemical pathways for the selective C(sp3)-Ge bond formation |
| title_short | Switchable electrochemical pathways for the selective C(sp3)-Ge bond formation |
| title_sort | switchable electrochemical pathways for the selective c sp3 ge bond formation |
| url | https://doi.org/10.1038/s41467-025-62141-x |
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