Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases
Fasting hyperlipidemia results from lipid metabolism defects associated with alterations in specific lipoprotein classes. These changes may originate from genetic predispositions or underlying metabolic disorders, including cholestasis and endocrine diseases. This retrospective study aimed to analyz...
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2025-01-01
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| author | Tae-Woo Kim Min-Hee Kang Hee-Myung Park |
| author_facet | Tae-Woo Kim Min-Hee Kang Hee-Myung Park |
| author_sort | Tae-Woo Kim |
| collection | DOAJ |
| description | Fasting hyperlipidemia results from lipid metabolism defects associated with alterations in specific lipoprotein classes. These changes may originate from genetic predispositions or underlying metabolic disorders, including cholestasis and endocrine diseases. This retrospective study aimed to analyze variations in lipoprotein electrophoresis (LPE) profiles in hyperlipidemic dogs and investigate the associations between biliary tract diseases, endocrine disorders, and lipid metabolism. Sixty-five dogs that underwent LPE were classified into non-hyperlipidemic (NHL) and hyperlipidemic (HL) groups, with further subdivisions based on the presence of biliary tract disease, endocrine disorders, or breed predisposition (Miniature Schnauzers). Dogs in the HL group with biliary tract disease and those with underlying metabolic disorders exhibited significantly higher pre-beta fractions and cholesterol concentrations compared to the NHL group. Additionally, significant linear relationships were observed between serum gamma-glutamyl transpeptidase (GGT) levels and both pre-beta fractions and cholesterol concentrations. The Schnauzer group showed lower alpha fractions and higher triglyceride and cholesterol levels than the NHL group. These findings suggest that LPE is a valuable and useful tool for detecting lipid metabolism abnormalities. Clinicians should consider the potential for altered lipid metabolism when evaluating patients with biliary tract or endocrine diseases in small animal practice. |
| format | Article |
| id | doaj-art-bc63744320024e5d9805c0591c0614f9 |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-bc63744320024e5d9805c0591c0614f92025-01-24T13:18:18ZengMDPI AGAnimals2076-26152025-01-0115225610.3390/ani15020256Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine DiseasesTae-Woo Kim0Min-Hee Kang1Hee-Myung Park2Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Bio-Animal Health, Jangan University, Hwaseong 18331, Republic of KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaFasting hyperlipidemia results from lipid metabolism defects associated with alterations in specific lipoprotein classes. These changes may originate from genetic predispositions or underlying metabolic disorders, including cholestasis and endocrine diseases. This retrospective study aimed to analyze variations in lipoprotein electrophoresis (LPE) profiles in hyperlipidemic dogs and investigate the associations between biliary tract diseases, endocrine disorders, and lipid metabolism. Sixty-five dogs that underwent LPE were classified into non-hyperlipidemic (NHL) and hyperlipidemic (HL) groups, with further subdivisions based on the presence of biliary tract disease, endocrine disorders, or breed predisposition (Miniature Schnauzers). Dogs in the HL group with biliary tract disease and those with underlying metabolic disorders exhibited significantly higher pre-beta fractions and cholesterol concentrations compared to the NHL group. Additionally, significant linear relationships were observed between serum gamma-glutamyl transpeptidase (GGT) levels and both pre-beta fractions and cholesterol concentrations. The Schnauzer group showed lower alpha fractions and higher triglyceride and cholesterol levels than the NHL group. These findings suggest that LPE is a valuable and useful tool for detecting lipid metabolism abnormalities. Clinicians should consider the potential for altered lipid metabolism when evaluating patients with biliary tract or endocrine diseases in small animal practice.https://www.mdpi.com/2076-2615/15/2/256biliary tract diseaseendocrine diseasehyperlipidemialipid metabolismlipoprotein electrophoresis |
| spellingShingle | Tae-Woo Kim Min-Hee Kang Hee-Myung Park Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases Animals biliary tract disease endocrine disease hyperlipidemia lipid metabolism lipoprotein electrophoresis |
| title | Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases |
| title_full | Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases |
| title_fullStr | Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases |
| title_full_unstemmed | Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases |
| title_short | Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases |
| title_sort | lipid metabolism alterations in hyperlipidemic dogs with biliary tract or endocrine diseases |
| topic | biliary tract disease endocrine disease hyperlipidemia lipid metabolism lipoprotein electrophoresis |
| url | https://www.mdpi.com/2076-2615/15/2/256 |
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