Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication.
Type 2diabetes is a major health problem that affects the majority of advanced and developing countries at the same limit ,type 2 diabetes is characterized by insulin resistance which generated after metabolic syndrome induction due to weight gain and low physical activity ,also characterized by ins...
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Zagazig University, Faculty of Pharmacy
2025-06-01
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| Series: | Zagazig Journal of Pharmaceutical Sciences |
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| Online Access: | https://zjps.journals.ekb.eg/article_427593_d365649dd34ff8fe9f0030161df0865c.pdf |
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| author | Gehad Abdelazeem Elshamy Hany M El-Bassossy Shimaa Elshazly Nesreen Elkomy |
| author_facet | Gehad Abdelazeem Elshamy Hany M El-Bassossy Shimaa Elshazly Nesreen Elkomy |
| author_sort | Gehad Abdelazeem Elshamy |
| collection | DOAJ |
| description | Type 2diabetes is a major health problem that affects the majority of advanced and developing countries at the same limit ,type 2 diabetes is characterized by insulin resistance which generated after metabolic syndrome induction due to weight gain and low physical activity ,also characterized by insufficiency of pancreatic beta cells and progressive destruction of those cells due to oxidative stress produced by permenant hyperglycemia and hyperlipidemia. The major concern of type 2 diabetes is its complications .Acute complications of type 2 diabetes are diabetic ketoacidosis , diabetic coma,hypoglycemia or hyperglycemia,chronic complications are divided into microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular (ischemic heart disease, peripheral vascular disease, and cerebrovascular disease). Those complications act as a burden on health and economic organizations so finding a proper, available and safe medication was a great concern to many countries to reduce the load on economic and health organizations. There are many oral drug classes introduced for treating type 2 diabetes one of them is sulphonylurea .they act by secretagogue activity and the most commonly used drug of this class is glimepiride which is considered as the most effective and the safest one of them but it has some side effects like weight gain, hypoglycemia, and destruction of beta-cell after a short duration of reaching the maximal dose so many experimental and clinical trials are done to improve its safety profile. |
| format | Article |
| id | doaj-art-bc628fa0ef6f4316939e7ee92e66a3e8 |
| institution | Kabale University |
| issn | 1110-5089 2356-9786 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Zagazig University, Faculty of Pharmacy |
| record_format | Article |
| series | Zagazig Journal of Pharmaceutical Sciences |
| spelling | doaj-art-bc628fa0ef6f4316939e7ee92e66a3e82025-08-20T03:33:38ZengZagazig University, Faculty of PharmacyZagazig Journal of Pharmaceutical Sciences1110-50892356-97862025-06-013411930doi:10.21608/zjps.2025.346060.1084Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication.Gehad Abdelazeem Elshamy0Hany M El-Bassossy1 Shimaa Elshazly2 Nesreen Elkomy3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig UniversityDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig UniversityDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig UniversityDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig UniversityType 2diabetes is a major health problem that affects the majority of advanced and developing countries at the same limit ,type 2 diabetes is characterized by insulin resistance which generated after metabolic syndrome induction due to weight gain and low physical activity ,also characterized by insufficiency of pancreatic beta cells and progressive destruction of those cells due to oxidative stress produced by permenant hyperglycemia and hyperlipidemia. The major concern of type 2 diabetes is its complications .Acute complications of type 2 diabetes are diabetic ketoacidosis , diabetic coma,hypoglycemia or hyperglycemia,chronic complications are divided into microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular (ischemic heart disease, peripheral vascular disease, and cerebrovascular disease). Those complications act as a burden on health and economic organizations so finding a proper, available and safe medication was a great concern to many countries to reduce the load on economic and health organizations. There are many oral drug classes introduced for treating type 2 diabetes one of them is sulphonylurea .they act by secretagogue activity and the most commonly used drug of this class is glimepiride which is considered as the most effective and the safest one of them but it has some side effects like weight gain, hypoglycemia, and destruction of beta-cell after a short duration of reaching the maximal dose so many experimental and clinical trials are done to improve its safety profile.https://zjps.journals.ekb.eg/article_427593_d365649dd34ff8fe9f0030161df0865c.pdftype 2 diabetes mellitussulphonylureasglimepirideadd-on therapy |
| spellingShingle | Gehad Abdelazeem Elshamy Hany M El-Bassossy Shimaa Elshazly Nesreen Elkomy Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication. Zagazig Journal of Pharmaceutical Sciences type 2 diabetes mellitus sulphonylureas glimepiride add-on therapy |
| title | Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication. |
| title_full | Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication. |
| title_fullStr | Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication. |
| title_full_unstemmed | Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication. |
| title_short | Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication. |
| title_sort | improving the glimepiride efficacy in type 2 diabetes treatment a review of the potential advantages and disadvantages of glimepiride as hypoglycemic oral medication |
| topic | type 2 diabetes mellitus sulphonylureas glimepiride add-on therapy |
| url | https://zjps.journals.ekb.eg/article_427593_d365649dd34ff8fe9f0030161df0865c.pdf |
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