Mid-term outcomes of the Absorb BVS versus second-generation DES: A systematic review and meta-analysis.
<h4>Background</h4>Bioresorbable Vascular Scaffolds (BVS) were introduced to overcome some of the limitations of drug-eluting stent (DES) for PCI. Data regarding the clinical outcomes of the BVS versus DES beyond 2 years are emerging.<h4>Objective</h4>To study mid-term outcom...
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0197119 |
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| author | Cordula M Felix Victor J van den Berg Sanne E Hoeks Jiang Ming Fam Mattie Lenzen Eric Boersma Peter C Smits Patrick W Serruys Yoshinobu Onuma Robert Jan M van Geuns |
| author_facet | Cordula M Felix Victor J van den Berg Sanne E Hoeks Jiang Ming Fam Mattie Lenzen Eric Boersma Peter C Smits Patrick W Serruys Yoshinobu Onuma Robert Jan M van Geuns |
| author_sort | Cordula M Felix |
| collection | DOAJ |
| description | <h4>Background</h4>Bioresorbable Vascular Scaffolds (BVS) were introduced to overcome some of the limitations of drug-eluting stent (DES) for PCI. Data regarding the clinical outcomes of the BVS versus DES beyond 2 years are emerging.<h4>Objective</h4>To study mid-term outcomes.<h4>Methods</h4>We searched online databases (PubMed/Medline, Embase, CENTRAL), several websites, meeting presentations and scientific session abstracts until August 8th, 2017 for studies comparing Absorb BVS with second-generation DES. The primary outcome was target lesion failure (TLF). Secondary outcomes were all-cause mortality, myocardial infarction, target lesion revascularization (TLR) and definite/probable device thrombosis. Odds ratios (ORs) with 95% confidence intervals (CIs) were derived using a random effects model.<h4>Results</h4>Ten studies, seven randomized controlled trials and three propensity-matched observational studies, with a total of 7320 patients (BVS n = 4007; DES n = 3313) and a median follow-up duration of 30.5 months, were included. Risk of TLF was increased for BVS-treated patients (OR 1.34 [95% CI: 1.12-1.60], p = 0.001, I2 = 0%). This was also the case for all myocardial infarction (1.58 [95% CI: 1.27-1.96], p<0.001, I2 = 0%), TLR (1.48 [95% CI: 1.19-1.85], p<0.001, I2 = 0%) and definite/probable device thrombosis (of 2.82 (95% CI: 1.86-3.89], p<0.001 and I2 = 40.3%). This did not result in a difference in all-cause mortality (0.78 [95% CI: 0.58-1.04], p = 0.09, I2 = 0%). OR for very late (>1 year) device thrombosis was 6.10 [95% CI: 1.40-26.65], p = 0.02).<h4>Conclusion</h4>At mid-term follow-up, BVS was associated with an increased risk of TLF, MI, TLR and definite/probable device thrombosis, but this did not result in an increased risk of all-cause mortality. |
| format | Article |
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| language | English |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-bc5f665aae4749bb87e249fe9c0c92f22025-08-20T02:20:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01135e019711910.1371/journal.pone.0197119Mid-term outcomes of the Absorb BVS versus second-generation DES: A systematic review and meta-analysis.Cordula M FelixVictor J van den BergSanne E HoeksJiang Ming FamMattie LenzenEric BoersmaPeter C SmitsPatrick W SerruysYoshinobu OnumaRobert Jan M van Geuns<h4>Background</h4>Bioresorbable Vascular Scaffolds (BVS) were introduced to overcome some of the limitations of drug-eluting stent (DES) for PCI. Data regarding the clinical outcomes of the BVS versus DES beyond 2 years are emerging.<h4>Objective</h4>To study mid-term outcomes.<h4>Methods</h4>We searched online databases (PubMed/Medline, Embase, CENTRAL), several websites, meeting presentations and scientific session abstracts until August 8th, 2017 for studies comparing Absorb BVS with second-generation DES. The primary outcome was target lesion failure (TLF). Secondary outcomes were all-cause mortality, myocardial infarction, target lesion revascularization (TLR) and definite/probable device thrombosis. Odds ratios (ORs) with 95% confidence intervals (CIs) were derived using a random effects model.<h4>Results</h4>Ten studies, seven randomized controlled trials and three propensity-matched observational studies, with a total of 7320 patients (BVS n = 4007; DES n = 3313) and a median follow-up duration of 30.5 months, were included. Risk of TLF was increased for BVS-treated patients (OR 1.34 [95% CI: 1.12-1.60], p = 0.001, I2 = 0%). This was also the case for all myocardial infarction (1.58 [95% CI: 1.27-1.96], p<0.001, I2 = 0%), TLR (1.48 [95% CI: 1.19-1.85], p<0.001, I2 = 0%) and definite/probable device thrombosis (of 2.82 (95% CI: 1.86-3.89], p<0.001 and I2 = 40.3%). This did not result in a difference in all-cause mortality (0.78 [95% CI: 0.58-1.04], p = 0.09, I2 = 0%). OR for very late (>1 year) device thrombosis was 6.10 [95% CI: 1.40-26.65], p = 0.02).<h4>Conclusion</h4>At mid-term follow-up, BVS was associated with an increased risk of TLF, MI, TLR and definite/probable device thrombosis, but this did not result in an increased risk of all-cause mortality.https://doi.org/10.1371/journal.pone.0197119 |
| spellingShingle | Cordula M Felix Victor J van den Berg Sanne E Hoeks Jiang Ming Fam Mattie Lenzen Eric Boersma Peter C Smits Patrick W Serruys Yoshinobu Onuma Robert Jan M van Geuns Mid-term outcomes of the Absorb BVS versus second-generation DES: A systematic review and meta-analysis. PLoS ONE |
| title | Mid-term outcomes of the Absorb BVS versus second-generation DES: A systematic review and meta-analysis. |
| title_full | Mid-term outcomes of the Absorb BVS versus second-generation DES: A systematic review and meta-analysis. |
| title_fullStr | Mid-term outcomes of the Absorb BVS versus second-generation DES: A systematic review and meta-analysis. |
| title_full_unstemmed | Mid-term outcomes of the Absorb BVS versus second-generation DES: A systematic review and meta-analysis. |
| title_short | Mid-term outcomes of the Absorb BVS versus second-generation DES: A systematic review and meta-analysis. |
| title_sort | mid term outcomes of the absorb bvs versus second generation des a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0197119 |
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