Outcomes of COVID-19 patients with comorbidities in southwest Nigeria.
<h4>Background</h4>Data on the comorbidities that result in negative outcomes for people with COVID-19 are currently scarce for African populations. This study identifies comorbidities that predict death among a large sample of COVID-19 patients from Nigeria.<h4>Methods</h4>T...
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Public Library of Science (PLoS)
2021-01-01
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| author | Akin Osibogun Mobolanle Balogun Akin Abayomi Jide Idris Yetunde Kuyinu Oluwakemi Odukoya Ololade Wright Remi Adeseun Bamidele Mutiu Babatunde Saka Nike Osa Dayo Lajide Ismael Abdus-Salam Bodunrin Osikomaiya Oluwatosin Onasanya Bisola Adebayo Yewande Oshodi Sunday Adesola Olu Adejumo Olufemi Erinoso Hussein Abdur-Razzaq Abimbola Bowale Kingsley Akinroye |
| author_facet | Akin Osibogun Mobolanle Balogun Akin Abayomi Jide Idris Yetunde Kuyinu Oluwakemi Odukoya Ololade Wright Remi Adeseun Bamidele Mutiu Babatunde Saka Nike Osa Dayo Lajide Ismael Abdus-Salam Bodunrin Osikomaiya Oluwatosin Onasanya Bisola Adebayo Yewande Oshodi Sunday Adesola Olu Adejumo Olufemi Erinoso Hussein Abdur-Razzaq Abimbola Bowale Kingsley Akinroye |
| author_sort | Akin Osibogun |
| collection | DOAJ |
| description | <h4>Background</h4>Data on the comorbidities that result in negative outcomes for people with COVID-19 are currently scarce for African populations. This study identifies comorbidities that predict death among a large sample of COVID-19 patients from Nigeria.<h4>Methods</h4>This was a retrospective analysis of medical records for 2184 laboratory confirmed cases of COVID-19 in Lagos, southwest Nigeria. Extracted data included age, sex, severity of condition at presentation and self-reported comorbidities. The outcomes of interest were death or discharge from facility.<h4>Results</h4>Most of the cases were male (65.8%) and the median age was 43 years (IQR: 33-55). Four hundred and ninety-two patients (22.5%) had at least one comorbidity and the most common amongst them were hypertension (74.2%) and diabetes (30.3%). The mortality rate was 3.3% and a significantly higher proportion of patients with comorbidities died compared to those with none. The comorbidities that predicted death were hypertension (OR: 2.21, 95%CI: 1.22-4.01), diabetes (OR: 3.69, 95% CI: 1.99-6.85), renal disease (OR: 12.53, 95%CI: 1.97-79.56), cancer (OR: 14.12, 95% CI: 2.03-98.19) and HIV (OR: 1.77-84.15].<h4>Conclusion</h4>Comorbidities are prevalent and the associated risk of death is high among COVID-19 patients in Lagos, Nigeria. Public enlightenment, early identification and targeted care for COVID-19 cases with comorbidities are recommended as the pandemic evolves. |
| format | Article |
| id | doaj-art-bc5eaef4b0fc4a51855af1e47afad506 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-bc5eaef4b0fc4a51855af1e47afad5062025-08-20T02:00:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01163e024828110.1371/journal.pone.0248281Outcomes of COVID-19 patients with comorbidities in southwest Nigeria.Akin OsibogunMobolanle BalogunAkin AbayomiJide IdrisYetunde KuyinuOluwakemi OdukoyaOlolade WrightRemi AdeseunBamidele MutiuBabatunde SakaNike OsaDayo LajideIsmael Abdus-SalamBodunrin OsikomaiyaOluwatosin OnasanyaBisola AdebayoYewande OshodiSunday AdesolaOlu AdejumoOlufemi ErinosoHussein Abdur-RazzaqAbimbola BowaleKingsley Akinroye<h4>Background</h4>Data on the comorbidities that result in negative outcomes for people with COVID-19 are currently scarce for African populations. This study identifies comorbidities that predict death among a large sample of COVID-19 patients from Nigeria.<h4>Methods</h4>This was a retrospective analysis of medical records for 2184 laboratory confirmed cases of COVID-19 in Lagos, southwest Nigeria. Extracted data included age, sex, severity of condition at presentation and self-reported comorbidities. The outcomes of interest were death or discharge from facility.<h4>Results</h4>Most of the cases were male (65.8%) and the median age was 43 years (IQR: 33-55). Four hundred and ninety-two patients (22.5%) had at least one comorbidity and the most common amongst them were hypertension (74.2%) and diabetes (30.3%). The mortality rate was 3.3% and a significantly higher proportion of patients with comorbidities died compared to those with none. The comorbidities that predicted death were hypertension (OR: 2.21, 95%CI: 1.22-4.01), diabetes (OR: 3.69, 95% CI: 1.99-6.85), renal disease (OR: 12.53, 95%CI: 1.97-79.56), cancer (OR: 14.12, 95% CI: 2.03-98.19) and HIV (OR: 1.77-84.15].<h4>Conclusion</h4>Comorbidities are prevalent and the associated risk of death is high among COVID-19 patients in Lagos, Nigeria. Public enlightenment, early identification and targeted care for COVID-19 cases with comorbidities are recommended as the pandemic evolves.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248281&type=printable |
| spellingShingle | Akin Osibogun Mobolanle Balogun Akin Abayomi Jide Idris Yetunde Kuyinu Oluwakemi Odukoya Ololade Wright Remi Adeseun Bamidele Mutiu Babatunde Saka Nike Osa Dayo Lajide Ismael Abdus-Salam Bodunrin Osikomaiya Oluwatosin Onasanya Bisola Adebayo Yewande Oshodi Sunday Adesola Olu Adejumo Olufemi Erinoso Hussein Abdur-Razzaq Abimbola Bowale Kingsley Akinroye Outcomes of COVID-19 patients with comorbidities in southwest Nigeria. PLoS ONE |
| title | Outcomes of COVID-19 patients with comorbidities in southwest Nigeria. |
| title_full | Outcomes of COVID-19 patients with comorbidities in southwest Nigeria. |
| title_fullStr | Outcomes of COVID-19 patients with comorbidities in southwest Nigeria. |
| title_full_unstemmed | Outcomes of COVID-19 patients with comorbidities in southwest Nigeria. |
| title_short | Outcomes of COVID-19 patients with comorbidities in southwest Nigeria. |
| title_sort | outcomes of covid 19 patients with comorbidities in southwest nigeria |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248281&type=printable |
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