Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides

Multispanning membrane protein SIDT2 increases knockdown activity of gapmer antisense oligonucleotides

Abstract Recent advances in the clinical development of oligonucleotide therapeutics, such as antisense oligonucleotides (ASOs) and small interfering RNAs, have attracted attention as promising therapeutic modalities for genetic and intractable diseases. These oligonucleotide therapeutics exert thei...

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Bibliographic Details
Main Authors: Kohshi Kusumoto, Kiyomi Sasaki, Yasunori Uchida, Ayaka Utsumi, Tokuyuki Yoshida, Satoshi Obika, Takao Inoue, Keiichiro Okuhira
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Antisense oligonucleotide
Gapmer
Endosomal escape
Oligonucleotide therapeutics
SIDT1
SIDT2
Online Access:https://doi.org/10.1038/s41598-024-84310-6
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